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NS 11021

(HB1047)
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Product overview

Name NS 11021
Purity >95%
Description Potent, selective KCa1.1 channel activator
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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NS 11021 product vial image | Hello Bio
NS 11021 product vial image | Hello Bio

NS 11021 product vial image | Hello Bio

NS 11021 product vial image | Hello Bio

Biological Data

Biological description Potent and selective KCa1.1 channel activator. Alters gating kinetics of KCa channels, increasing the open channel probability without affecting single channel conductance. Exhibits approx 10 times higher potency than NS 1619. Displays cytoprotective properties.

Solubility & Handling

Solubility overview Soluble in ethanol (100mM) or DMSO (100mM)
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name N'-[3,5-Bis(trifluoromethyl)phenyl]-N-[4-bromo-2-(2H-tetrazol-5-yl-phenyl]thiourea
Molecular Weight 511.24
Chemical structure NS 11021 [956014-19-0] Chemical Structure
Molecular Formula C16H9BrF6N6S
CAS Number 956014-19-0
PubChem identifier 24825677
SMILES BrC1=CC(C2=NN=NN2)=C(NC(NC3=CC(C(F)(F)F)=CC(C(F)(F)F)=C3)=S)C=C1
InChi InChI=1S/C16H9BrF6N6S/c17-9-1-2-12(11(6-9)13-26-28-29-27-13)25-14(30)24-10-4-7(15(18,19)20)3-8(5-10)16(21,22)23/h1-6H,(H2,24,25,30)(H,26,27,28,29)
InChiKey MDKAFDIKYQMOMF-UHFFFAOYSA-N
MDL number MFCD25563257

References for NS 11021

References are publications that support the biological activity of the product

  • Pharmacological activation of mitochondrial BK(Ca) channels protects isolated cardiomyocytes against simulated reperfusion-induced injury.

    Borchert GH et al (2013) Exp Biol Med (Maywood) 238(2) : 233-41.
    Read more (PubMedID: 23576804)

  • Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury.

    Bentzen BH et al (2009) Pflugers Arch 457(5) : 979-88.
    Read more (PubMedID: 18762970)

  • The small molecule NS11021 is a potent and specific activator of Ca2+-activated big-conductance K+ channels.

    Bentzen BH et al (2007) Mol Pharmacol 72(4) : 1033-44.
    Read more (PubMedID: 17636045)

3 Item(s)

Grouped product items
Order: HB1047
Pack PriceQty
1mg
$35
5mg
$113
10mg
$172
25mg
$386
Potent, selective KCa1.1 channel activator
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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