Competitive and selective protein kinase C (PKC) inhibitor (IC50 = 19.0 µM) that interacts at N terminal of C1 domain. Shows selectivity for PKC-α over PKC-HH and PKC-CB (IC50 values are 22, 30, 130 µM respectively). Exhibits little or no activity for cAMP-dependent or calcium/calmodulin-dependent protein kinase (IC50 values >300 µM). Displays neuroprotective properties.
Solubility & Handling
Solubility overview
Soluble in water or DMSO
Storage instructions
+4°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
2,6-Diamino-N-([1-(1-oxotridecyl)-2-piperidinyl] methyl)hexanamide (NPC 15437): a novel inhibitor of protein kinase C interacting at the regulatory domain.
Sullivan JP et al (1992) Mol Pharmacol 41(1) : 38-44.
![NPC-15437 dihydrochloride [136449-85-9] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0457.png "NPC-15437 dihydrochloride [136449-85-9]")
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