Product overview

Name MS 436
Purity >98%
Description Potent, selective BRD4 bromodomain inhibitor
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Biological Data

Biological description Potent and selective BRD4 bromodomain inhibitor (Ki = 30-50 nM). Selective for the first over the second bromodomain. Inhibits the activity of BRD4 in macrophage nitric oxide and Il-6 production. Alters colony integrity in embryonic stem cells. Shows antiproliferative and anticancer actions.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >98%
Chemical name (E)-4-[2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide
Molecular Weight 383.42
Chemical structure MS 436   [1395084-25-9] Chemical Structure
Molecular Formula C18H17N5O3S
CAS Number 1395084-25-9
PubChem identifier 60171585
SMILES NC1=C(/N=N/C2=CC=C(S(NC3=NC=CC=C3)(=O)=O)C=C2)C=C(C)C(O)=C1

References for MS 436

References are publications that support the biological activity of the product
  • Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes.

    Di Micco R et al (2014) Cell Rep 9(1) : 234-47.
  • BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy.

    Segura MF et al (2013) Cancer Res 73(20) : 6264-76.
  • Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains.

    Zhang G et al (2013) J Med Chem 56(22) : 9251-64.

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