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MS 436

(HB1450)
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Product overview

Name MS 436
Purity >98%
Description Potent, selective BRD4 bromodomain inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Potent and selective BRD4 bromodomain inhibitor (Ki = 30-50 nM). Selective for the first over the second bromodomain. Inhibits the activity of BRD4 in macrophage nitric oxide and Il-6 production. Alters colony integrity in embryonic stem cells. Shows antiproliferative and anticancer actions.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (E)-4-[2-(2-Amino-4-hydroxy-5-methylphenyl)diazenyl]-N-2-pyridinylbenzenesulfonamide
Molecular Weight 383.42
Chemical structure MS 436 [1395084-25-9] Chemical Structure
Molecular Formula C18H17N5O3S
CAS Number 1395084-25-9
PubChem identifier 60171585
SMILES NC1=C(/N=N/C2=CC=C(S(NC3=NC=CC=C3)(=O)=O)C=C2)C=C(C)C(O)=C1
InChiKey BBJDRANVVNBXAR-JWGURIENSA-N

References for MS 436

References are publications that support the biological activity of the product

  • Control of embryonic stem cell identity by BRD4-dependent transcriptional elongation of super-enhancer-associated pluripotency genes.

    Di Micco R et al (2014) Cell Rep 9(1) : 234-47.
    Read more (PubMedID: 25263550)

  • BRD4 sustains melanoma proliferation and represents a new target for epigenetic therapy.

    Segura MF et al (2013) Cancer Res 73(20) : 6264-76.
    Read more (PubMedID: 23950209)

  • Structure-guided design of potent diazobenzene inhibitors for the BET bromodomains.

    Zhang G et al (2013) J Med Chem 56(22) : 9251-64.
    Read more (PubMedID: 24144283)

3 Item(s)

Grouped product items
Order: HB1450
Pack PriceQty
5mg
$140
25mg
$565
Potent, selective BRD4 bromodomain inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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