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Images
ML-7 hydrochloride product vial image | Hello Bio
ML-7 hydrochloride product vial image | Hello Bio
Biological Data
| Biological description | Selective myosin light chain kinase (MLCK) inhibitor (Ki = 0.3 µM). Shows reversible ATP- competitive inhibition of Ca2+ calmodulin independent/ dependant smooth muscle MLCK. Approx 10-fold more potent inhibitor than ML-9 Shows antiglaucomatous actions. |
Solubility & Handling
| Storage instructions | room temperature (desiccate) |
| Solubility overview | Soluble in DMSO (25mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride |
| Chemical structure | ![ML-7 [110448-33-4] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "ML-7 [110448-33-4]") |
| Molecular Formula | C15H17IN2O2S.HCl |
| PubChem identifier | 9803932 |
| SMILES | C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CC=C3I.Cl |
| InChiKey | KDDALCDYHZIZMH-UHFFFAOYSA-N |
References for ML-7 hydrochloride
References are publications that support the biological activity of the product
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Effects of ML-7 and Y-27632 on carbachol- and endothelin-1-induced contraction of bovine trabecular meshwork.
Rosenthal R et al (2005) Exp Eye Res 80(6) : 837-45. -
The specificities of protein kinase inhibitors: an update.
Bain J et al (2003) Biochem J 371(Pt 1) : 199-204. -
Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase.
Saitoh M et al (1987) J Biol Chem 262(16) : 7796-801.
![ML-7 [110448-33-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0415_1.png "ML-7 [110448-33-4]")
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