Product overview

Name ML-7 hydrochloride
Purity >99%
Description Selective MLCK inhibitor
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Biological Data

Biological description Selective myosin light chain kinase (MLCK) inhibitor (Ki = 0.3 µM). Shows reversible ATP- competitive inhibition of Ca2+ calmodulin independent/ dependant smooth muscle MLCK. Approx 10-fold more potent inhibitor than ML-9 Shows antiglaucomatous actions.

Solubility & Handling

Storage instructions room temperature (desiccate)
Solubility overview Soluble in DMSO (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >99%
Chemical name Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride
Molecular Weight 452.74
Chemical structure ML-7  [110448-33-4] Chemical Structure
Molecular Formula C15H17IN2O2S.HCl
CAS Number 110448-33-4
PubChem identifier 9803932
SMILES C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CC=C3I.Cl
InChiKey KDDALCDYHZIZMH-UHFFFAOYSA-N

References for ML-7 hydrochloride

References are publications that support the biological activity of the product
  • Effects of ML-7 and Y-27632 on carbachol- and endothelin-1-induced contraction of bovine trabecular meshwork.

    Rosenthal R et al (2005) Exp Eye Res 80(6) : 837-45.
  • The specificities of protein kinase inhibitors: an update.

    Bain J et al (2003) Biochem J 371(Pt 1) : 199-204.
  • Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase.

    Saitoh M et al (1987) J Biol Chem 262(16) : 7796-801.

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