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ML-7 hydrochloride

(HB0415)
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Product overview

Name ML-7 hydrochloride
Purity >99%
Description Selective MLCK inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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ML-7 hydrochloride product vial image | Hello Bio
ML-7 hydrochloride product vial image | Hello Bio

ML-7 hydrochloride product vial image | Hello Bio

ML-7 hydrochloride product vial image | Hello Bio

Biological Data

Biological description Selective myosin light chain kinase (MLCK) inhibitor (Ki = 0.3 µM). Shows reversible ATP- competitive inhibition of Ca2+ calmodulin independent/ dependant smooth muscle MLCK. Approx 10-fold more potent inhibitor than ML-9 Shows antiglaucomatous actions.

Solubility & Handling

Solubility overview Soluble in DMSO (25mM)
Storage instructions room temperature (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name Hexahydro-1-[(5-iodo-1-naphthalenyl)sulfonyl]-1H-1,4-diazepine hydrochloride
Molecular Weight 452.74
Chemical structure ML-7 [110448-33-4] Chemical Structure
Molecular Formula C15H17IN2O2S.HCl
CAS Number 110448-33-4
PubChem identifier 9803932
SMILES C1CNCCN(C1)S(=O)(=O)C2=CC=CC3=C2C=CC=C3I.Cl
InChiKey KDDALCDYHZIZMH-UHFFFAOYSA-N

References for ML-7 hydrochloride

References are publications that support the biological activity of the product

  • Effects of ML-7 and Y-27632 on carbachol- and endothelin-1-induced contraction of bovine trabecular meshwork.

    Rosenthal R et al (2005) Exp Eye Res 80(6) : 837-45.
    Read more (PubMedID: 15939040)

  • The specificities of protein kinase inhibitors: an update.

    Bain J et al (2003) Biochem J 371(Pt 1) : 199-204.
    Read more (PubMedID: 12534346)

  • Selective inhibition of catalytic activity of smooth muscle myosin light chain kinase.

    Saitoh M et al (1987) J Biol Chem 262(16) : 7796-801.
    Read more (PubMedID: 3108259)

3 Item(s)

Grouped product items
Order: HB0415
Pack PriceQty
25mg
$296
Selective MLCK inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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