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Biological Data

Biological description Akt inhibitor. Inhibits T-cell proliferation and HIV-1 cell survival and production. Displays anti-inflammatory and anticancer properties with broad spectrum of fungicidal and antiamoebae activities. Blood brain barrier permeable.

Solubility & Handling

Storage instructions -20°C
Solubility overview

Soluble in water (25 mM)

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 1-Hexadecylphosphorylcholine
Molecular Weight 407.6
Chemical structure Miltefosine  [58066-85-6] Chemical Structure
Molecular Formula

C21H46NO4P

CAS Number 58066-85-6
PubChem identifier 3599
SMILES CCCCCCCCCCCCCCCCOP(=O)([O-])OCC[N+](C)(C)C

References for Miltefosine

References are publications that support the biological activity of the product
  • Miltefosine suppresses inflammation in a mouse model of inflammatory bowel disease.

    Verhaar AP et al (2013) Inflamm Bowel Dis 19(9) : 1974-82.
  • Miltefosine enhances phagocytosis but decreases nitric oxide production by peritoneal macrophages of C57BL/6 mice.

    Ponte CB et al (2012) Int Immunopharmacol 13(1) : 114-9.
  • Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy.

    Chugh P et al (2008) Retrovirology 5 : 11