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Mepyramine maleate

(HB2622)
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Product overview

Name Mepyramine maleate
Alternative names Pyrilamine maleate
Purity >98%
Description Selective H1 receptor inverse agonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Biological Data

Biological description Selective H1 receptor inverse agonist. Selective for H1 over H2, H3 and H4 receptors (Ki values are 0.4 nM, 5.2, >10 and >10 µM respectively). Also a potent KCNQ/M potassium channel blocker. Shows anti-allergic and neuroexcitatory actions. Blood-brain barrier permeable.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in water (100 mM) and in DMSO (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 2-((2-(Dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridine maleate
Molecular Weight 401.46
Chemical structure Mepyramine maleate Chemical Structure
Molecular Formula C17H23N3O.C4H4O4
CAS Number 59-33-6
PubChem identifier 5284451
SMILES CN(C)CCN(CC1=CC=C(C=C1)OC)C2=CC=CC=N2.C(=C\C(=O)O)\C(=O)O
InChi InChI=1S/C17H23N3O.C4H4O4/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15;5-3(6)1-2-4(7)8/h4-11H,12-14H2,1-3H3;1-2H,(H,5,6)(H,7,8)/b;2-1-
InChiKey JXYWFNAQESKDNC-BTJKTKAUSA-N
MDL number MFCD00069333
Appearance White solid

References for Mepyramine maleate

References are publications that support the biological activity of the product

  • Antihistamine mepyramine directly inhibits KCNQ/M channel and depolarizes rat superior cervical ganglion neurons.

    Liu B et al (2008) Neuropharmacology 54(4) : 629-39.
    Read more (PubMedID: 18222495)

  • Histamine and its receptors.

    Parsons ME et al (2006) Br J Pharmacol 147 Suppl 1 : S127-35.
    Read more (PubMedID: 16402096)

  • Transport mechanism of an H1-antagonist at the blood-brain barrier: transport mechanism of mepyramine using the carotid injection technique.

    Yamazaki M et al (1994) Biol Pharm Bull 17(5) : 676-9.
    Read more (PubMedID: 7920432)

3 Item(s)

Grouped product items
Order: HB2622
Pack PriceQty
100mg
$46
Selective H1 receptor inverse agonist
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Hazardous: $35

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