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Biological Data
| Biological description | Free fatty acid 1 (FFA1/GPR40) receptor agonist. Inhibits ATP-citrate lyase and decreases hepatic acetyl-CoA carboxylase activity and plasma triacylglycerol. Sensitizes adipose tissue to insulin. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 3,3,14,14-Tetramethylhexadecanedioic acid |
| Chemical structure | ![MEDICA 16 [87272-20-6] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "MEDICA 16 [87272-20-6]") |
| Molecular Formula | C20H38O4 |
| PubChem identifier | 121871 |
| SMILES | CC(CC(O)=O)(C)CCCCCCCCCCC(C)(C)CC(O)=O |
| InChiKey | HYSMCRNFENOHJH-UHFFFAOYSA-N |
References for MEDICA 16
References are publications that support the biological activity of the product
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Novel selective ligands for free fatty acid receptors GPR120 and GPR40.
Hara T et al (2009) Naunyn Schmiedebergs Arch Pharmacol 380(3) : 247-55. -
Adipose tissue sensitization to insulin induced by troglitazone and MEDICA 16 in obese Zucker rats in vivo.
Kalderon B et al (2003) Am J Physiol Endocrinol Metab 284(4) : E795-803. -
MEDICA 16 inhibits hepatic acetyl-CoA carboxylase and reduces plasma triacylglycerol levels in insulin-resistant JCR: LA-cp rats.
Atkinson LL et al (2002) Diabetes 51(5) : 1548-55.
Free fatty acid 1 (FFA1) receptor agonist
![MEDICA 16 [87272-20-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0877.png "MEDICA 16 [87272-20-6]")
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