Product overview
| Name | Margatoxin |
| Description | Potent, non-selective Kv1.3 channel blocker |
| Alternative names | MgTX |
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Biological Data
| Biological description | Potent and non-selective Kv1.3 channel blocker (IC50 = approx. 30 pM; Kd = 11.7 pM). Also inhibits Kv1.2 and Kv1.1 channels (Kd values are 6.4 pM and 4.2 nM respectively). Blocks VEGF-induced Ca2+ entry and hyperpolarisation of endothelial cells. |
Solubility & Handling
| Storage instructions | -20°C |
| Solubility overview | Soluble in water |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Molecular Weight | 4178.96 |
| Molecular Formula | C178H286N52O50S7 |
| CAS Number | 145808-47-5 |
| PubChem identifier | 121596045 |
| SMILES | [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CO)NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC2=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(O)=O |
| InChiKey | OVJBOPBBHWOWJI-FYNXUGHNSA-N |
References for Margatoxin
References are publications that support the biological activity of the product
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Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels.
Bartok A et al (2014) Toxicon 87 : 6-16. -
Margatoxin inhibits VEGF-induced hyperpolarization, proliferation and nitric oxide production of human endothelial cells.
Erdogan A et al (2005) J Vasc Res 42(5) : 368-76. -
Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels.
Garcia-Calvo M et al (1993) J Biol Chem 268(25) : 18866-74.
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