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Margatoxin

(HB1083)
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Product overview

Name Margatoxin
Alternative names MgTX
Purity >95%
Description Potent, non-selective Kv1.3 channel blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Biological Data

Biological description Potent and non-selective Kv1.3 channel blocker (IC50 = approx. 30 pM; Kd = 11.7 pM). Also inhibits Kv1.2 and Kv1.1 channels (Kd values are 6.4 pM and 4.2 nM respectively). Blocks VEGF-induced Ca2+ entry and hyperpolarisation of endothelial cells.

Solubility & Handling

Solubility overview Soluble in water
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >95%
Molecular Weight 4178.96
Molecular Formula C178H286N52O50S7
CAS Number 145808-47-5
PubChem identifier 121596045
SMILES [H]N[C@@H]([C@@H](C)O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@H]1CSSC[C@@H]2NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CC3=CC=CC=C3)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]3CSSC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]4CCCN4C(=O)[C@H](CO)NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N3)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCSC)NC2=O)C(=O)N[C@@H](CC1=CC=C(O)C=C1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC1=CNC=N1)C(O)=O
InChiKey OVJBOPBBHWOWJI-FYNXUGHNSA-N

References for Margatoxin

References are publications that support the biological activity of the product

  • Margatoxin is a non-selective inhibitor of human Kv1.3 K+ channels.

    Bartok A et al (2014) Toxicon 87 : 6-16.
    Read more (PubMedID: 24878374)

  • Margatoxin inhibits VEGF-induced hyperpolarization, proliferation and nitric oxide production of human endothelial cells.

    Erdogan A et al (2005) J Vasc Res 42(5) : 368-76.
    Read more (PubMedID: 16043967)

  • Purification, characterization, and biosynthesis of margatoxin, a component of Centruroides margaritatus venom that selectively inhibits voltage-dependent potassium channels.

    Garcia-Calvo M et al (1993) J Biol Chem 268(25) : 18866-74.
    Read more (PubMedID: 8360176)

3 Item(s)

Grouped product items
Order: HB1083
Pack PriceQty
100μg
$432
Potent, non-selective Kv1.3 channel blocker
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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