LY 333531 hydrochloride

Name: LY 333531 hydrochloride
SKU: HB0393

(HB0393)

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Technical documents: Datasheet

Product overview

Name

LY 333531 hydrochloride

Alternative names

Ruboxistaurin

Description

Potent, selective, competitive PKC inhibitor

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) References (3)

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Biological Data

Biological description

Potent, selective and competitive protein kinase C (PKC) inhibitor. Selective for PKCβI and PKCβII (IC₅₀ values are 4.7 and 5.9 nM respectively) over PKCα by 76- and 61- fold respectively. Shows antinociceptive actions against and improves vascular function in diabetes.

Solubility & Handling

Storage instructions

-20°C

Solubility overview

Soluble in DMSO (20mM)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name

(9S)-9-[(Dimethylamino)methyl]-6,7, 10,11-tetrahydro-9H,18H-5,21:12,17-dimethenodibenz o[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecin e-18,20(19H)-dione hydrochloride

Molecular Weight

505.01

Chemical structure

Molecular Formula

C₂₈H₂₈N₄O₃.HCl

CAS Number

169939-93-9

PubChem identifier

9870785

SMILES

O=C(C(C4=CN(CCO[C@H](CN(C)C)CC6)C5=C4C=CC=C5)=C1C2=CN6C3=CC=CC=C23)NC1=O.Cl

InChiKey

NYQIEYDJYFVLPO-FERBBOLQSA-N

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for LY 333531 hydrochloride

References are publications that support the biological activity of the product

Protein kinase Cbeta selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons.
Kim H et al (2003) Diabetes 52(8) : 2102-9.
Read more (PubMedID: 12882929)
Effects of the protein kinase C beta inhibitor LY333531 on neural and vascular function in rats with streptozotocin-induced diabetes.
Cotter MA et al (2002) Clin Sci (Lond) 103(3) : 311-21.
Read more (PubMedID: 12193157)
(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.
Jirousek MR et al (1996) J Med Chem 39(14) : 2664-71.
Read more (PubMedID: 8709095)

Potent, selective, competitive PKC inhibitor

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LY 333531 hydrochloride

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for LY 333531 hydrochloride

Protein kinase Cbeta selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons.

Effects of the protein kinase C beta inhibitor LY333531 on neural and vascular function in rats with streptozotocin-induced diabetes.

(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.

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LY 333531 hydrochloride

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for LY 333531 hydrochloride

Protein kinase Cbeta selective inhibitor LY333531 attenuates diabetic hyperalgesia through ameliorating cGMP level of dorsal root ganglion neurons.

Effects of the protein kinase C beta inhibitor LY333531 on neural and vascular function in rats with streptozotocin-induced diabetes.

(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.

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About you

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