Potent, selective and competitive protein kinase C (PKC) inhibitor. Selective for PKCβI and PKCβII (IC50 values are 4.7 and 5.9 nM respectively) over PKCα by 76- and 61- fold respectively. Shows antinociceptive actions against and improves vascular function in diabetes.
Solubility & Handling
Solubility overview
Soluble in DMSO (20mM)
Storage instructions
-20°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
(S)-13-[(dimethylamino)methyl]-10,11,14,15-tetrahydro-4,9:16, 21-dimetheno-1H, 13H-dibenzo[e,k]pyrrolo[3,4-h][1,4,13]oxadiazacyclohexadecene-1,3(2H)-d ione (LY333531) and related analogues: isozyme selective inhibitors of protein kinase C beta.
Jirousek MR et al (1996) J Med Chem 39(14) : 2664-71.
![LY 333531 hydrochloride [169939-93-9] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0393.png "LY 333531 hydrochloride [169939-93-9]")
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