Product overview
Name | L-threo-Sphingosine C-18 |
Description | PKC inhibitor |
Alternative names | L-threo-C18-sphingosine |
Purity | >98% |
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Biological Data
Biological description | Protein kinase C (PKC) inhibitor. D-erythro-sphingosine analog. |
Solubility & Handling
Solubility overview | Soluble in ethanol |
Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
Chemical name | (2S,3S,4E)-2-aminooctadec-4-ene-1,3-diol |
Molecular Weight | 299.5 |
Chemical structure | |
Molecular Formula | C18H37NO2 |
CAS Number | 25695-95-8 |
References for L-threo-Sphingosine C-18
References are publications that support the biological activity of the product
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Sphingolipid biosynthesis in cultured neurons. Down-regulation of serine palmitoyltransferase by sphingoid bases.
Mandon EC et al (1991) Eur J Biochem 198(3) : 667-74. -
Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds.
Merrill AH Jr et al (1989) Biochemistry 28(8) : 3138-45.