Product overview

Name L-threo-Sphingosine C-18
Description PKC inhibitor
Alternative names L-threo-C18-sphingosine
Purity >98%
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Biological Data

Biological description Protein kinase C (PKC) inhibitor. D-erythro-sphingosine analog.

Solubility & Handling

Solubility overview Soluble in ethanol
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Chemical name (2S,3S,4E)-2-aminooctadec-4-ene-1,3-diol
Molecular Weight 299.5
Chemical structure L-threo-Sphingosine C-18  [25695-95-8] Chemical Structure
Molecular Formula C18H37NO2
CAS Number 25695-95-8

References for L-threo-Sphingosine C-18

References are publications that support the biological activity of the product
  • Sphingolipid biosynthesis in cultured neurons. Down-regulation of serine palmitoyltransferase by sphingoid bases.

    Mandon EC et al (1991) Eur J Biochem 198(3) : 667-74.
  • Structural requirements for long-chain (sphingoid) base inhibition of protein kinase C in vitro and for the cellular effects of these compounds.

    Merrill AH Jr et al (1989) Biochemistry 28(8) : 3138-45.