Product overview

Name K-252b
Purity >98%
Description Potent PKC and casein kinase II inhibitor
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Biological Data

Biological description Potent protein kinase C (PKC) and casein kinase II inhibitor (IC50 = 38.3 nM at PKC). Inhibits neurotrophic factor and nerve growth factor.

Solubility & Handling

Solubility overview Soluble in DMSO (1mg/ml) or DMF (1mg/ml)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name Staurosporine Aglycone
Molecular Weight 453.45
Chemical structure K-252b  [99570-78-2] Chemical Structure
Molecular Formula C26H19N3O5
CAS Number 99570-78-2
PubChem identifier 9846716
SMILES CC12C(CC(O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)(C(=O)O)O

References for K-252b

References are publications that support the biological activity of the product
  • K-252b, c and d, potent inhibitors of protein kinase C from microbial origin.

    Nakanishi S et al (1986) J Antibiot (Tokyo) 39(8) : 1066-71.
  • K-252b, c and d, potent inhibitors of protein kinase C from microbial origin.

    Nakanishi S et al (1986) J Antibiot (Tokyo) 39(8) : 1066-71.

2 Item(s)