Product overview

Name JIB 04
Description Jumonji histone demethylase inhibitor
Alternative names JIB-04
Purity >99%
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Biological Data

Biological description Jumonji histone demethylase inhibitor. Inhibits JARID1A, JMJD2E/2B/2A/D3/2C (IC50 values are 230, 340, 435, 445, 855 and 1100 nM respectively). Shows little activity at PHD2 (IC50 = > 6 µM) and TET1. Shows anti-cancer actions.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name 5-Chloro-2-[(E)-2-[phenyl(pyridin-2-yl)methylidene]hydrazin-1-yl]pyridine
Molecular Weight 308.76
Chemical structure JIB 04  [199596-05-9] Chemical Structure
Molecular Formula C17H13ClN4
CAS Number 199596-05-9
PubChem identifier 6519698
SMILES ClC(C=C3)=CN=C3N/N=C(C2=CC=CC=C2)/C1=CC=CC=N1
InChiKey YHHFKWKMXWRVTJ-OQKWZONESA-N

References for JIB 04

References are publications that support the biological activity of the product
  • A small molecule modulates Jumonji histone demethylase activity and selectively inhibits cancer growth.

    Wang L et al (2013) Nat Commun 4 : 2035