Product overview

Name ICI 63197
Purity >98%
Description Potent, selective cAMP PDE inhibitor
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ICI 63197 product vial image | Hello Bio

Biological Data

Biological description Potent and selective cAMP phosphodiesterase (PDE) inhibitor (IC50 = 35 nM). Shows higher affinity for PDE4 (Ki = 312.9 nM). Displays antihyperthermic and antidepressant properties.

Solubility & Handling

Storage instructions +4°C
Solubility overview

Soluble in DMSO (100mM), and in ethanol (100 mM)

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Chemical Data

Purity >98%
Chemical name 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one
Molecular Weight 207.23
Chemical structure ICI 63197  [27277-00-5] Chemical Structure
Molecular Formula C9H13N5O
CAS Number 27277-00-5
PubChem identifier 62824
SMILES CCCN1C(=O)C(=CN2C1=NC(=N2)N)C
InChi InChI=1S/C9H13N5O/c1-3-4-13-7(15)6(2)5-14-9(13)11-8(10)12-14/h5H,3-4H2,1-2H3,(H2,10,12)
InChiKey UQDVRVNMIJAGRK-UHFFFAOYSA-N
MDL number MFCD06407961

References for ICI 63197

References are publications that support the biological activity of the product
  • Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram.

    Zhao Y et al (2003) J Pharmacol Exp Ther 305(2) : 565-72.
  • Autoradiographic mapping of a selective cyclic adenosine monophosphate phosphodiesterase in rat brain with the antidepressant [3H]rolipram.

    Kaulen P et al (1989) Brain Res 503(2) : 229-45.
  • Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors.

    Wachtel H (1983) Neuropharmacology 22(3) : 267-72.

3 Item(s)