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Images
ICI 63197 product vial image | Hello Bio
ICI 63197 product vial image | Hello Bio
Biological Data
| Biological description | Potent and selective cAMP phosphodiesterase (PDE) inhibitor (IC50 = 35 nM). Shows higher affinity for PDE4 (Ki = 312.9 nM). Displays antihyperthermic and antidepressant properties. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM), and in ethanol (100 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use |
Chemical Data
| Chemical name | 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one |
| Chemical structure | ![ICI 63197 [27277-00-5] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "ICI 63197 [27277-00-5]") |
| Molecular Formula | C9H13N5O |
| SMILES | CCCN1C(=O)C(=CN2C1=NC(=N2)N)C |
| InChi | InChI=1S/C9H13N5O/c1-3-4-13-7(15)6(2)5-14-9(13)11-8(10)12-14/h5H,3-4H2,1-2H3,(H2,10,12) |
| InChiKey | UQDVRVNMIJAGRK-UHFFFAOYSA-N |
References for ICI 63197
References are publications that support the biological activity of the product
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Inhibitor binding to type 4 phosphodiesterase (PDE4) assessed using [3H]piclamilast and [3H]rolipram.
Zhao Y et al (2003) J Pharmacol Exp Ther 305(2) : 565-72. -
Autoradiographic mapping of a selective cyclic adenosine monophosphate phosphodiesterase in rat brain with the antidepressant [3H]rolipram.
Kaulen P et al (1989) Brain Res 503(2) : 229-45. -
Potential antidepressant activity of rolipram and other selective cyclic adenosine 3',5'-monophosphate phosphodiesterase inhibitors.
Wachtel H (1983) Neuropharmacology 22(3) : 267-72.
Potent, selective cAMP PDE inhibitor
![ICI 63197 [27277-00-5] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0332.png "ICI 63197 [27277-00-5]")
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