Product overview
| Name | Honokiol |
| Description | Phosphoinositide 3-kinase (PI3K)/Akt pathway inhibitor |
| Purity | >98% |
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Biological Data
| Biological description | Phosphoinositide 3-kinase (PI3K)/Akt pathway inhibitor. Inhibits NO, prostaglandin E2 and TNF-α production. Inhibits NFκB and scavenges superoxide and peroxyl radicals. Shows anti-inflammatory, antitumor and anti-angiogenic actions. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100 mM) and in ethanol (100 mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 3,5'-Diallyl-4,2'-dihydroxybiphenyl |
| Molecular Weight | 266.33 |
| Chemical structure | ![Honokiol [35354-74-6] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0328.png "Honokiol [35354-74-6]") |
| Molecular Formula | C18H18O2 |
| CAS Number | 35354-74-6 |
| PubChem identifier | 72303 |
| SMILES | C=CCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)O)CC=C |
| InChi | InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2 |
| InChiKey | FVYXIJYOAGAUQK-UHFFFAOYSA-N |
| MDL number | MFCD00016674 |
References for Honokiol
References are publications that support the biological activity of the product
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Honokiol is a potent scavenger of superoxide and peroxyl radicals.
Dikalov S et al (2008) Biochem Pharmacol 76(5) : 589-96. -
Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression.
Kim BH et al (2008) Acta Pharmacol Sin 29(1) : 113-22. -
Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells.
Yang SE et al (2002) Biochem Pharmacol 63(9) : 1641-51. -
Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages.
Son HJ et al (2000) Planta Med 66(5) : 469-71.
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