Product overview

Name Honokiol
Description Phosphoinositide 3-kinase (PI3K)/Akt pathway inhibitor
Purity >98%
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Biological Data

Biological description Phosphoinositide 3-kinase (PI3K)/Akt pathway inhibitor. Inhibits NO, prostaglandin E2 and TNF-α production. Inhibits NFκB and scavenges superoxide and peroxyl radicals. Shows anti-inflammatory, antitumor and anti-angiogenic actions.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100 mM) and in ethanol (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 3,5'-Diallyl-4,2'-dihydroxybiphenyl
Molecular Weight 266.33
Chemical structure Honokiol  [35354-74-6] Chemical Structure
Molecular Formula C18H18O2
CAS Number 35354-74-6
PubChem identifier 72303
SMILES C=CCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)O)CC=C
InChi InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
InChiKey FVYXIJYOAGAUQK-UHFFFAOYSA-N
MDL number MFCD00016674

References for Honokiol

References are publications that support the biological activity of the product
  • Honokiol is a potent scavenger of superoxide and peroxyl radicals.

    Dikalov S et al (2008) Biochem Pharmacol 76(5) : 589-96.
  • Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression.

    Kim BH et al (2008) Acta Pharmacol Sin 29(1) : 113-22.
  • Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells.

    Yang SE et al (2002) Biochem Pharmacol 63(9) : 1641-51.
  • Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages.

    Son HJ et al (2000) Planta Med 66(5) : 469-71.