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Images Honokiol product vial image | Hello Bio
Honokiol product vial image | Hello Bio Biological Data Biological description Phosphoinositide 3-kinase (PI3K)/Akt pathway inhibitor. Inhibits NO, prostaglandin E2 and TNF-α production. Inhibits NFκB and scavenges superoxide and peroxyl radicals. Shows anti-inflammatory, antitumor and anti-angiogenic actions.
Solubility & Handling Storage instructions +4°C
Solubility overview Soluble in DMSO (100 mM) and in ethanol (100 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 3,5'-Diallyl-4,2'-dihydroxybiphenyl
Chemical structure
Molecular Formula C18 H18 O2
SMILES C=CCC1=CC(=C(C=C1)O)C2=CC(=C(C=C2)O)CC=C
InChi InChI=1S/C18H18O2/c1-3-5-13-7-9-18(20)16(11-13)14-8-10-17(19)15(12-14)6-4-2/h3-4,7-12,19-20H,1-2,5-6H2
InChiKey FVYXIJYOAGAUQK-UHFFFAOYSA-N
References for Honokiol References are publications that support the biological activity of the product
Honokiol is a potent scavenger of superoxide and peroxyl radicals. Dikalov S et al (2008) Biochem Pharmacol 76(5) : 589-96. Anti-inflammatory effect of honokiol is mediated by PI3K/Akt pathway suppression. Kim BH et al (2008) Acta Pharmacol Sin 29(1) : 113-22. Down-modulation of Bcl-XL, release of cytochrome c and sequential activation of caspases during honokiol-induced apoptosis in human squamous lung cancer CH27 cells. Yang SE et al (2002) Biochem Pharmacol 63(9) : 1641-51. Inhibitors of nitric oxide synthesis and TNF-alpha expression from Magnolia obovata in activated macrophages. Son HJ et al (2000) Planta Med 66(5) : 469-71.
Phosphoinositide 3-kinase (PI3K)/Akt pathway inhibitor
![Honokiol [35354-74-6] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0328.png "Honokiol [35354-74-6]")
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