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Biological Data

Biological description Src family kinase inhibitor. Inhibits Hsp90 in the heat shock response. Inhibits IκB kinase β and suppresses NF-κB. Shows anti-inflammatory, antibiotic and anti-angiogenic actions.

Solubility & Handling

Storage instructions -20°C
Solubility overview Soluble in DMSO (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name (15R)-17-demethoxy-15-methoxy-11-O- methyl-geldanamycin
Molecular Weight 574.67
Molecular Formula C30H42N2O9
CAS Number 70563-58-5
PubChem identifier 6436247
SMILES O=C1C=C([C@H](OC)[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O
InChiKey MCAHMSDENAOJFZ-GDYSMBPZSA-N

References for Herbimycin A

References are publications that support the biological activity of the product
  • Inhibition of Hsp90 function delays and impairs recovery from heat shock.

    Duncan RF (2005) FEBS J 272(20) : 5244-56.
  • Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity.

    McCollum GW et al (2004) Exp Eye Res 78(5) : 987-95.
  • Herbimycin A abrogates nuclear factor-kappaB activation by interacting preferentially with the IkappaB kinase beta subunit.

    Ogino S et al (2004) Mol Pharmacol 65(6) : 1344-51.