Herbimycin A

Name: Herbimycin A
SKU: HB1325
Price: 728 USD
Availability: InStock

(HB1325)

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Technical documents: Datasheet

Product overview

Name

Herbimycin A

Purity

>99%

Description

Src family kinase inhibitor

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) References (3)

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Biological Data

Biological description

Src family kinase inhibitor. Inhibits Hsp90 in the heat shock response. Inhibits IκB kinase β and suppresses NF-κB. Shows anti-inflammatory, antibiotic and anti-angiogenic actions.

Solubility & Handling

Storage instructions

-20°C

Solubility overview

Soluble in DMSO (10mM)

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>99%

Chemical name

(15R)-17-demethoxy-15-methoxy-11-O- methyl-geldanamycin

Molecular Weight

574.67

Molecular Formula

C₃₀H₄₂N₂O₉

CAS Number

70563-58-5

PubChem identifier

6436247

SMILES

O=C1C=C([C@H](OC)[C@@H](C)C[C@H](OC)[C@H](OC)[C@@H](C)/C=C(C)/[C@H](OC(N)=O)[C@@H](OC)/C=C/C=C(C)/C2=O)C(C(N2)=C1)=O

InChiKey

MCAHMSDENAOJFZ-GDYSMBPZSA-N

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for Herbimycin A

References are publications that support the biological activity of the product

Inhibition of Hsp90 function delays and impairs recovery from heat shock.
Duncan RF (2005) FEBS J 272(20) : 5244-56.
Read more (PubMedID: 16218955)
Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity.
McCollum GW et al (2004) Exp Eye Res 78(5) : 987-95.
Read more (PubMedID: 15051479)
Herbimycin A abrogates nuclear factor-kappaB activation by interacting preferentially with the IkappaB kinase beta subunit.
Ogino S et al (2004) Mol Pharmacol 65(6) : 1344-51.
Read more (PubMedID: 15155828)

Src family kinase inhibitor

Order: HB1325
Pack	Price	Qty
500μg	$728

Herbimycin A

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for Herbimycin A

Inhibition of Hsp90 function delays and impairs recovery from heat shock.

Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity.

Herbimycin A abrogates nuclear factor-kappaB activation by interacting preferentially with the IkappaB kinase beta subunit.

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Herbimycin A

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for Herbimycin A

Inhibition of Hsp90 function delays and impairs recovery from heat shock.

Herbimycin A inhibits angiogenic activity in endothelial cells and reduces neovascularization in a rat model of retinopathy of prematurity.

Herbimycin A abrogates nuclear factor-kappaB activation by interacting preferentially with the IkappaB kinase beta subunit.

About you

Tell us about your publication!

Captcha

About you

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New Products in this Area