Product overview

Name H-8
Purity >98%
Description PKA / PKG inhibitor
Write Your Own Review
You're reviewing:H-8
Rate this item:

Biological Data

Biological description PKG (cGPK), PKA, PKC, Myosin light chain kinase (MLCK), Casein kinase (CK) 1 and 2 inhibitor (Ki values are 0.48, 1.2, 15, 68, 133 and 950 µM respectively). Blocks cell cycle progression.

Solubility & Handling

Solubility overview Soluble in DMSO (25mg/ml) or ethanol:water (25mg/ml, ratio 1:1)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

=
x
x
More Info

Dilution

x
=
x
More Info

Chemical Data

Purity >98%
Chemical name N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamidedihydrochloride
Molecular Weight 338.25
Chemical structure H-8  [84478-11-5] Chemical Structure
Molecular Formula C12H15N3O2S.2HCl
CAS Number 84478-11-5
PubChem identifier 150584
SMILES CNCCNS(=O)(=O)C1=CC=CC2=C1C=CN=C2.Cl.Cl

References for H-8

References are publications that support the biological activity of the product
  • Differential growth inhibition of isoquinolinesulfonamides H-8 and H-7 towards multidrug-resistant P388 murine leukaemia cells.

    Ido M et al (1991) Br J Cancer 64(6) : 1103-7.
  • Differential growth inhibition of isoquinolinesulfonamides H-8 and H-7 towards multidrug-resistant P388 murine leukaemia cells.

    Ido M et al (1991) Br J Cancer 64(6) : 1103-7.
  • Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.

    Hidaka H et al (1984) Biochemistry 23(21) : 5036-41.

3 Item(s)