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Biological Data

Biological description PKG (cGPK), PKA, PKC, Myosin light chain kinase (MLCK), Casein kinase (CK) 1 and 2 inhibitor (Ki values are 0.48, 1.2, 15, 68, 133 and 950 µM respectively). Blocks cell cycle progression.

Solubility & Handling

Solubility overview Soluble in DMSO (25mg/ml) or ethanol:water (25mg/ml, ratio 1:1)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Chemical name N-[2-(methylamino)ethyl]isoquinoline-5-sulfonamidedihydrochloride
Molecular Weight 338.25
Chemical structure H-8  [84478-11-5] Chemical Structure
Molecular Formula C12H15N3O2S.2HCl
CAS Number 84478-11-5
PubChem identifier 150584
SMILES CNCCNS(=O)(=O)C1=CC=CC2=C1C=CN=C2.Cl.Cl

References for H-8

References are publications that support the biological activity of the product
  • Differential growth inhibition of isoquinolinesulfonamides H-8 and H-7 towards multidrug-resistant P388 murine leukaemia cells.

    Ido M et al (1991) Br J Cancer 64(6) : 1103-7.
  • Differential growth inhibition of isoquinolinesulfonamides H-8 and H-7 towards multidrug-resistant P388 murine leukaemia cells.

    Ido M et al (1991) Br J Cancer 64(6) : 1103-7.
  • Isoquinolinesulfonamides, novel and potent inhibitors of cyclic nucleotide dependent protein kinase and protein kinase C.

    Hidaka H et al (1984) Biochemistry 23(21) : 5036-41.