The store will not work correctly in the case when cookies are disabled.
Biological Data
| Biological description | Dehydrogenase enzyme inhibitor. Bcl-2 homology 3 (BH3)-mimetic agent, binds to the BH3 domain of members of the B-cell lymphoma 2 (Bcl-2) family. Inhibits APE-1 (apurinic/apyrimidinic endonuclease 1) activity. Shows antioxidant, antiviral, antiparasitic, apoptotic and anticancer actions. |
Solubility & Handling
| Solubility overview | Soluble in ethanol (25mg/ml) or DMF (25mg/ml) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | Pogosin; AT101 |
| Chemical structure | ![Gossypol [303-45-7] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Gossypol [303-45-7]") |
| Molecular Formula | C30H30O8 |
| SMILES | CC1=C(C(=C2C(=C1)C(=C(C(=C2C=O)O)O)C(C)C)O)C3=C(C=C4C(=C3O)C(=C(C(=C4C(C)C)O)O)C=O)C |
| InChiKey | QBKSWRVVCFFDOT-UHFFFAOYSA-N |
References for Gossypol
References are publications that support the biological activity of the product
-
Therapeutic potential of gossypol: an overview.
Keshmiri-Neghab H et al (2014) Pharm Biol 52(1) : 124-8. -
Identification of a novel potential antitumor activity of gossypol as an APE1/Ref-1 inhibitor.
Qian C et al (2014) Drug Des Devel Ther 8 : 485-96. -
Gossypol: a contraceptive for men.
Coutinho EM (2002) Contraception 65(4) : 259-63. -
Gossypol: prototype of inhibitors targeted to dinucleotide folds.
Vander Jagt DL et al (2000) Curr Med Chem 7(4) : 479-98.
Dehydrogenase enzyme inhibitor
![Gossypol [303-45-7] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0304.png "Gossypol [303-45-7]")
Understanding purity and quality - a guide for life scientists