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Go 6976

(HB0302)
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Product overview

Name Go 6976
Purity >98%
Description Potent, selective PKC inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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Biological Data

Biological description Potent and selective protein kinase C (PKC) inhibitor at α and β1 subunits (IC50 values are 2.3 and 6.2 nM respectively). Displays no activity at ε, δ, and ζ PKC subunits. Also a protein kinase D (IC50 = 20 nM), JAK 2, FLT3, TrkB and TrkA tyrosine kinases inhibitor. Displays antitumor properties.

Solubility & Handling

Solubility overview Soluble in DMSO
Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name 5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile
Molecular Weight 378.43
Chemical structure Go 6976 [136194-77-9] Chemical Structure
Molecular Formula C24H18N4O
CAS Number 136194-77-9
PubChem identifier 3501
SMILES CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O
InChiKey VWVYILCFSYNJHF-UHFFFAOYSA-N

References for Go 6976

References are publications that support the biological activity of the product

  • Gö6976 is a potent inhibitor of the JAK 2 and FLT3 tyrosine kinases with significant activity in primary acute myeloid leukaemia cells.

    Grandage VL et al (2006) Br J Haematol 135(3) : 303-16.
    Read more (PubMedID: 16956345)

  • Putative conventional protein kinase C inhibitor Gödecke 6976 [12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole] stimulates transglutaminase activity in primary mouse epidermal keratinocytes.

    Shapiro BA et al (2002) J Pharmacol Exp Ther 302(1) : 352-8.
    Read more (PubMedID: 12065737)

  • Gö 6976 is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase.

    Behrens MM et al (1999) J Neurochem 72(3) : 919-24.
    Read more (PubMedID: 10037462)

  • Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.

    Martiny-Baron G et al (1993) J Biol Chem 268(13) : 9194-7.
    Read more (PubMedID: 8486620)

4 Item(s)

Grouped product items
Order: HB0302
Pack PriceQty
1mg
$219
Potent, selective PKC inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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