Go 6976

Name: Go 6976
SKU: HB0302
Price: 213 USD
Availability: InStock

(HB0302)

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Technical documents: SDS Datasheet

Product overview

Name

Go 6976

Purity

>98%

Description

Potent, selective PKC inhibitor

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) References (4) Frequently bought together

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Biological Data

Biological description

Potent and selective protein kinase C (PKC) inhibitor at α and β1 subunits (IC₅₀ values are 2.3 and 6.2 nM respectively). Displays no activity at ε, δ, and ζ PKC subunits. Also a protein kinase D (IC₅₀ = 20 nM), JAK 2, FLT3, TrkB and TrkA tyrosine kinases inhibitor. Displays antitumor properties.

Solubility & Handling

Storage instructions

-20°C (desiccate)

Solubility overview

Soluble in DMSO

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>98%

Chemical name

5,6,7,13-Tetrahydro-13-methyl-5-oxo-12H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-12-propanenitrile

Molecular Weight

378.43

Chemical structure

Molecular Formula

C₂₄H₁₈N₄O

CAS Number

136194-77-9

PubChem identifier

3501

SMILES

CN1C2=CC=CC=C2C3=C4C(=C5C6=CC=CC=C6N(C5=C31)CCC#N)CNC4=O

InChiKey

VWVYILCFSYNJHF-UHFFFAOYSA-N

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for Go 6976

References are publications that support the biological activity of the product

Gö6976 is a potent inhibitor of the JAK 2 and FLT3 tyrosine kinases with significant activity in primary acute myeloid leukaemia cells.
Grandage VL et al (2006) Br J Haematol 135(3) : 303-16.
Read more (PubMedID: 16956345)
Putative conventional protein kinase C inhibitor Gödecke 6976 [12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole] stimulates transglutaminase activity in primary mouse epidermal keratinocytes.
Shapiro BA et al (2002) J Pharmacol Exp Ther 302(1) : 352-8.
Read more (PubMedID: 12065737)
Gö 6976 is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase.
Behrens MM et al (1999) J Neurochem 72(3) : 919-24.
Read more (PubMedID: 10037462)
Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.
Martiny-Baron G et al (1993) J Biol Chem 268(13) : 9194-7.
Read more (PubMedID: 8486620)

Potent, selective PKC inhibitor

Order: HB0302
Pack	Price	Qty
1mg	$213

Go 6976

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for Go 6976

Gö6976 is a potent inhibitor of the JAK 2 and FLT3 tyrosine kinases with significant activity in primary acute myeloid leukaemia cells.

Putative conventional protein kinase C inhibitor Gödecke 6976 [12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole] stimulates transglutaminase activity in primary mouse epidermal keratinocytes.

Gö 6976 is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase.

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.

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Go 6976

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for Go 6976

Gö6976 is a potent inhibitor of the JAK 2 and FLT3 tyrosine kinases with significant activity in primary acute myeloid leukaemia cells.

Putative conventional protein kinase C inhibitor Gödecke 6976 [12-(2-cyanoethyl)-6,7,12,13-tetrahydro-13-methyl-5-oxo-5H-indolo(2,3-a)pyrrolo(3,4-c)-carbazole] stimulates transglutaminase activity in primary mouse epidermal keratinocytes.

Gö 6976 is a potent inhibitor of neurotrophin-receptor intrinsic tyrosine kinase.

Selective inhibition of protein kinase C isozymes by the indolocarbazole Gö 6976.

About you

Tell us about your publication!

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About you

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New Products in this Area