Cell permeable immunosuppressor which displays lymphocyte sequestration properties. It is a sphingosine 1-phosphate (S1P) receptor modulator (S1P1, S1P3, S1P4, and S1P5) when phosphorylated by sphingosine kinase.
It also enhances activity of Sphingosine transporter Abcb1 and leukotriene C4 transporter Abcc1 and inhibits Cytosolic phospholipase A2 independent of sphingosine 1-phosphate receptors.
It induces autophagy and apoptosis and shows immunosuppresant actions. Also suppresses the development of the multiple sclreosis EAE model.
Recently investigated as part of COVID-19 compound repurposing.
Solubility & Handling
Storage instructions
+4°C
Solubility overview
Soluble in DMSO
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.