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Fostriecin sodium salt

(HB0293)
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Product overview

Name Fostriecin sodium salt
Purity >98%
Description Potent protein phosphatase inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Fostriecin sodium salt product vial image | Hello Bio
Fostriecin sodium salt product vial image | Hello Bio

Fostriecin sodium salt product vial image | Hello Bio

Fostriecin sodium salt product vial image | Hello Bio

Biological Data

Biological description

Potent protein phosphatase inhibitor. Inhibits PP4, PP2A, PP5C and PP1 (IC50 values are 3, 3.2 nM, 60 and 131 µM). Shows antibiotic and antitumor actions. Membrane permeable.

Solubility & Handling

Solubility overview Soluble in water (100mM)
Storage instructions -20°C (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name (6R)-5,6-Dihydro-6-[(1E,3R,4R,6R,7Z ,9Z,11E)-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H-pyran-2-one sodium salt
Molecular Weight 452.37
Chemical structure Fostriecin sodium salt [87860-39-7] Chemical Structure
Molecular Formula C19H26O9PNa
CAS Number 87860-39-7
PubChem identifier 73324802
SMILES CC(C=CC1CC=CC(=O)O1)(C(CC(C=CC=CC=CCO)O)OP(=O)(O)[O-])O.[Na+]
InChi InChI=1S/C19H27O9P.Na/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20;/h2-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26);/q;+1/p-1
InChiKey XBUIKNRVGYFSHL-UHFFFAOYSA-M
MDL number MFCD09971059

References for Fostriecin sodium salt

References are publications that support the biological activity of the product

  • Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death.

    Theobald B et al (2013) Mol Cancer Res 11(8) : 845-55.
    Read more (PubMedID: 23671329)

  • Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters.

    Hastie CJ et al (1998) FEBS Lett 431(3) : 357-61.
    Read more (PubMedID: 9714542)

  • Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A.

    Walsh AH et al (1997) FEBS Lett 416(3) : 230-4.
    Read more (PubMedID: 9373158)

3 Item(s)

Grouped product items
Order: HB0293
Pack PriceQty
10μg
$204
Potent protein phosphatase inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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