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Images Fostriecin sodium salt product vial image | Hello Bio
Fostriecin sodium salt product vial image | Hello Bio Biological Data Biological description Potent protein phosphatase inhibitor. Inhibits PP4, PP2A, PP5C and PP1 (IC50 values are 3, 3.2 nM, 60 and 131 µM). Shows antibiotic and antitumor actions. Membrane permeable.
Solubility & Handling Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (6R )-5,6-Dihydro-6-[(1E ,3R ,4R ,6R ,7Z ,9Z ,11E )-3,6,13-trihydroxy-3-methyl-4-(phosphonooxy)-1,7,9,11-tridecatetraenyl]-2H -pyran-2-one sodium salt
Chemical structure
Molecular Formula C19 H26 O9 PNa
PubChem identifier 73324802
SMILES CC(C=CC1CC=CC(=O)O1)(C(CC(C=CC=CC=CCO)O)OP(=O)(O)[O-])O.[Na+]
InChi InChI=1S/C19H27O9P.Na/c1-19(23,12-11-16-9-7-10-18(22)27-16)17(28-29(24,25)26)14-15(21)8-5-3-2-4-6-13-20;/h2-8,10-12,15-17,20-21,23H,9,13-14H2,1H3,(H2,24,25,26);/q;+1/p-1
InChiKey XBUIKNRVGYFSHL-UHFFFAOYSA-M
References for Fostriecin sodium salt References are publications that support the biological activity of the product
Suppression of Ser/Thr phosphatase 4 (PP4C/PPP4C) mimics a novel post-mitotic action of fostriecin, producing mitotic slippage followed by tetraploid cell death. Theobald B et al (2013) Mol Cancer Res 11(8) : 845-55. Purification of protein phosphatase 4 catalytic subunit: inhibition by the antitumour drug fostriecin and other tumour suppressors and promoters. Hastie CJ et al (1998) FEBS Lett 431(3) : 357-61. Fostriecin, an antitumor antibiotic with inhibitory activity against serine/threonine protein phosphatases types 1 (PP1) and 2A (PP2A), is highly selective for PP2A. Walsh AH et al (1997) FEBS Lett 416(3) : 230-4.
Potent protein phosphatase inhibitor
![Fostriecin sodium salt [87860-39-7] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0293.png "Fostriecin sodium salt [87860-39-7]")
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