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Biological Data
| Biological description | Selective glucocorticoid receptor agonist (Kd = 0.5 nM). Reduces expression of mast cells, suppresses mast cell degranulation, enhances eosinophil apoptosis and inhibits T cell proliferation. Potentiates Kv1 channel current (EC50 = 37 nM). Shows anti-inflammatory and anti-allergy actions. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in DMSO (50mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid fluoromethyl ester |
| Chemical structure | ![Fluticasone propionate [80474-14-2] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Fluticasone propionate [80474-14-2]") |
| Molecular Formula | C25H31F3O5S |
| PubChem identifier | 444036 |
| SMILES | O=C1C=C[C@@]2(C)C([C@@H](F)C[C@]3([H])[C@@](F)2[C@@H](O)C[C@@]4(C)[C@]([H])3C[C@@H](C)[C@](C(SCF)=O)4OC(CC)=O)=C1 |
| InChiKey | WMWTYOKRWGGJOA-CENSZEJFSA-N |
References for Fluticasone propionate
References are publications that support the biological activity of the product
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Basic research on virus-induced asthma exacerbation: inhibition of inflammatory chemokine expression by fluticasone propionate.
Matsukura S et al (2013) Int Arch Allergy Immunol 161 Suppl 2 : 84-92. -
Potentiation of the Kv1 family K(+) channel by cortisone analogues.
Pan Y et al (2012) ACS Chem Biol 7(10) : 1641-6. -
Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasone.
Zhang X et al (2000) Eur J Pharmacol 406(3) : 325-32. -
The anti-inflammatory profile of fluticasone propionate.
Johnson M (1995) Allergy 50(23 Suppl) : 11-4.
Selective glucocorticoid receptor agonist
![Fluticasone propionate [80474-14-2] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1091.png "Fluticasone propionate [80474-14-2]")
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