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Fluticasone propionate

(HB1091)
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Product overview

Name Fluticasone propionate
Description Selective glucocorticoid receptor agonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4)
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Biological Data

Biological description Selective glucocorticoid receptor agonist (Kd = 0.5 nM). Reduces expression of mast cells, suppresses mast cell degranulation, enhances eosinophil apoptosis and inhibits T cell proliferation. Potentiates Kv1 channel current (EC50 = 37 nM). Shows anti-inflammatory and anti-allergy actions.

Solubility & Handling

Solubility overview Soluble in DMSO (50mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name (6α,11β,16α,17α)-6,9-Difluoro-11-hydroxy-16-methyl-3-oxo-17-(1-oxopropoxy)androsta-1,4-diene-17-carbothioic acid fluoromethyl ester
Molecular Weight 500.57
Chemical structure Fluticasone propionate [80474-14-2] Chemical Structure
Molecular Formula C25H31F3O5S
CAS Number 80474-14-2
PubChem identifier 444036
SMILES O=C1C=C[C@@]2(C)C([C@@H](F)C[C@]3([H])[C@@](F)2[C@@H](O)C[C@@]4(C)[C@]([H])3C[C@@H](C)[C@](C(SCF)=O)4OC(CC)=O)=C1
InChiKey WMWTYOKRWGGJOA-CENSZEJFSA-N

References for Fluticasone propionate

References are publications that support the biological activity of the product

  • Basic research on virus-induced asthma exacerbation: inhibition of inflammatory chemokine expression by fluticasone propionate.

    Matsukura S et al (2013) Int Arch Allergy Immunol 161 Suppl 2 : 84-92.
    Read more (PubMedID: 23711858)

  • Potentiation of the Kv1 family K(+) channel by cortisone analogues.

    Pan Y et al (2012) ACS Chem Biol 7(10) : 1641-6.
    Read more (PubMedID: 22803826)

  • Enhancement of human eosinophil apoptosis by fluticasone propionate, budesonide, and beclomethasone.

    Zhang X et al (2000) Eur J Pharmacol 406(3) : 325-32.
    Read more (PubMedID: 11040338)

  • The anti-inflammatory profile of fluticasone propionate.

    Johnson M (1995) Allergy 50(23 Suppl) : 11-4.
    Read more (PubMedID: 7604948)

4 Item(s)

Grouped product items
Order: HB1091
Pack PriceQty
10mg
$238
25mg
$484
100mg
$1,445
Selective glucocorticoid receptor agonist
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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