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Biological Data Biological description Selective phosphatidylinositol phospholipase (PLC) inhibitor (IC50 = 9.6 µM). Inhibits mitochondrial respiration, ERK1/2 and p38 MAPK. Also activates Fas/CD95 death receptor. Displays antitumor and apoptosis -inducing properties.
Solubility & Handling Solubility overview Soluble in ethanol or DMSO
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name Edelfosine; 1-octadecyl-2-O-methyl-glycero-3-phosphocholine
Chemical structure
Molecular Formula C27 H58 NO6 P
PubChem identifier 6918215
SMILES CCCCCCCCCCCCCCCCCCOC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC
References for ET-18-OCH3 References are publications that support the biological activity of the product
Edelfosine and perifosine disrupt hepatic mitochondrial oxidative phosphorylation and induce the permeability transition. Burgeiro A et al (2013) Mitochondrion 13(1) : 25-35. The antitumor ether lipid edelfosine (ET-18-O-CH3) induces apoptosis in H-ras transformed human breast epithelial cells: by blocking ERK1/2 and p38 mitogen-activated protein kinases as potential targets. Na HK et al (2008) Asia Pac J Clin Nutr 17 Suppl 1 : 204-7. ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor. Mollinedo F et al (2004) Curr Med Chem 11(24) : 3163-84. Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. Powis G et al (1992) Cancer Res 52(10) : 2835-40.
![ET-18-OCH3 [77286-66-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0278.png "ET-18-OCH3 [77286-66-9]")
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