Product overview

Name ET-18-OCH3
Purity >95%
Description Selective PLC inhibitor
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Biological Data

Biological description Selective phosphatidylinositol phospholipase (PLC) inhibitor (IC50 = 9.6 µM). Inhibits mitochondrial respiration, ERK1/2 and p38 MAPK. Also activates Fas/CD95 death receptor. Displays antitumor and apoptosis -inducing properties.

Solubility & Handling

Solubility overview Soluble in ethanol or DMSO
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >95%
Chemical name Edelfosine; 1-octadecyl-2-O-methyl-glycero-3-phosphocholine
Molecular Weight 523.7
Chemical structure ET-18-OCH3  [77286-66-9] Chemical Structure
Molecular Formula C27H58NO6P
CAS Number 77286-66-9
PubChem identifier 6918215
SMILES CCCCCCCCCCCCCCCCCCOC[C@H](COP(=O)([O-])OCC[N+](C)(C)C)OC

References for ET-18-OCH3

References are publications that support the biological activity of the product
  • Edelfosine and perifosine disrupt hepatic mitochondrial oxidative phosphorylation and induce the permeability transition.

    Burgeiro A et al (2013) Mitochondrion 13(1) : 25-35.
  • The antitumor ether lipid edelfosine (ET-18-O-CH3) induces apoptosis in H-ras transformed human breast epithelial cells: by blocking ERK1/2 and p38 mitogen-activated protein kinases as potential targets.

    Na HK et al (2008) Asia Pac J Clin Nutr 17 Suppl 1 : 204-7.
  • ET-18-OCH3 (edelfosine): a selective antitumour lipid targeting apoptosis through intracellular activation of Fas/CD95 death receptor.

    Mollinedo F et al (2004) Curr Med Chem 11(24) : 3163-84.
  • Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues.

    Powis G et al (1992) Cancer Res 52(10) : 2835-40.

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