Selective phosphatidylinositol phospholipase (PLC) inhibitor (IC50 = 9.6 µM). Inhibits mitochondrial respiration, ERK1/2 and p38 MAPK. Also activates Fas/CD95 death receptor. Displays antitumor and apoptosis -inducing properties.
Solubility & Handling
Solubility overview
Soluble in ethanol or DMSO
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
The antitumor ether lipid edelfosine (ET-18-O-CH3) induces apoptosis in H-ras transformed human breast epithelial cells: by blocking ERK1/2 and p38 mitogen-activated protein kinases as potential targets.
Na HK et al (2008) Asia Pac J Clin Nutr 17 Suppl 1 : 204-7.
![ET-18-OCH3 [77286-66-9] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0278.png "ET-18-OCH3 [77286-66-9]")
Understanding purity and quality - a guide for life scientists