Ds(+)-threo-Isocitric acid trisodium salt

Technical documents: Datasheet

Product overview

Name Ds(+)-threo-Isocitric acid trisodium salt
Description Anticoagulant that retains platelets functionality
Purity >98%
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Biological Data

Biological description Anticoagulant that retains platelets functionality. Buffers Ca2+ activity in physiological range (~1mM). Bypasses the metabolic blockade, may permit heme biosynthesis but does not suffice to reverse the iron-restriction response. Stabilizes the iron-sulfur cluster and is predicted to restore aconitase to its 'high iron' conformation and thereby dissociates the PKC-associated signaling complexes whose hyperactivation impairs Epo responsiveness. Binds IDH (isocitrate dehydrogenase), an excellent candidate for participating, along with aconitase and PKC, in an iron restriction signalosome. Contributes to heme biosynthesis which may account for its greater potency in restoring erythroid differentiation.

Solubility & Handling

Storage instructions +4°C
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Chemical name (1R,2S)-1-Hydroxy-1,2,3-propanetricarboxylic acid
Molecular Weight 258.1
Chemical structure Ds(+)-threo-Isocitric acid trisodium salt [903507-52-8] Chemical Structure
CAS Number 903507-52-8
Appearance White solid