Product overview

Name D-erythro-Sphingosine
Purity >98%
Description PKC inhibitor
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Biological Data

Biological description Protein kinase C (PKC) inhibitor. Also TRPM3 channel activator (EC50 = 12 µM). Exhibits little or no activity for other TRP channels. Also inhibits platelet aggregation.

Solubility & Handling

Solubility overview Soluble in ethanol (25mg/ml, gentle warming) or DMSO (25mg/ml, methanol)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >98%
Chemical name Sphingosine, C18 chain
Molecular Weight 299.5
Molecular Formula C18H37NO2
CAS Number 123-78-4
PubChem identifier 5280335
SMILES CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO

References for D-erythro-Sphingosine

References are publications that support the biological activity of the product
  • A concise synthesis of a promising protein kinase C inhibitor: D-erythro-sphingosine.

    Pham VT et al (2007) Arch Pharm Res 30(1) : 22-7.
  • Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine [corrected].

    Grimm C et al (2005) Mol Pharmacol 67(3) : 798-805.
  • Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets.

    Khan WA et al (1991) Biochem J 278 ( Pt 2) : 387-92.

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