Product overview

Name D-erythro-Sphingosine
Description PKC inhibitor
Purity >98%
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Biological Data

Biological description Protein kinase C (PKC) inhibitor. Also TRPM3 channel activator (EC50 = 12 µM). Exhibits little or no activity for other TRP channels. Also inhibits platelet aggregation.

Solubility & Handling

Solubility overview Soluble in ethanol (25mg/ml, gentle warming) or DMSO (25mg/ml, methanol)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name Sphingosine, C18 chain
Molecular Weight 299.5
Molecular Formula C18H37NO2
CAS Number 123-78-4
PubChem identifier 5280335
SMILES CCCCCCCCCCCCC/C=C/[C@@H](O)[C@@H](N)CO

References for D-erythro-Sphingosine

References are publications that support the biological activity of the product
  • A concise synthesis of a promising protein kinase C inhibitor: D-erythro-sphingosine.

    Pham VT et al (2007) Arch Pharm Res 30(1) : 22-7.
  • Activation of the melastatin-related cation channel TRPM3 by D-erythro-sphingosine [corrected].

    Grimm C et al (2005) Mol Pharmacol 67(3) : 798-805.
  • Use of D-erythro-sphingosine as a pharmacological inhibitor of protein kinase C in human platelets.

    Khan WA et al (1991) Biochem J 278 ( Pt 2) : 387-92.