Product overview
| Name | Daidzein |
| Description | Estrogen receptors (ER) agonist. Phytoestrogen. |
| Purity | >98% |
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Biological Data
| Biological description | Estrogen receptors (ER) agonist. Soy phytoestrogen and genistein analog. Also shows activity at PPARs. Shows both estrogenic/anti-estrogenic activity, induces apoptosis and anticancer effects. Active in vivo. |
Solubility & Handling
| Storage instructions | -20°C (desiccate) |
| Solubility overview | Soluble in DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1- benzopyran-4-one |
| Molecular Weight | 254.24 |
| Chemical structure | ![Daidzein [486-66-8] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb2488.png "Daidzein [486-66-8]") |
| Molecular Formula | C15H10O4 |
| CAS Number | 486-66-8 |
| PubChem identifier | 5281708 |
| SMILES | C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)O)O |
| InChi | InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H |
| InChiKey | ZQSIJRDFPHDXIC-UHFFFAOYSA-N |
| MDL number | MFCD00016954 |
References for Daidzein
References are publications that support the biological activity of the product
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Daidzein induced apoptosis via down-regulation of Bcl-2/Bax and triggering of the mitochondrial pathway in BGC-823 cells.
Tang S et al (2013) Cell Biochem Biophys 65(2) : 197-202. -
Daidzein causes cell cycle arrest at the G1 and G2/M phases in human breast cancer MCF-7 and MDA-MB-453 cells.
Choi EJ et al (2008) Phytomedicine 15(9) : 683-90. -
Isoflavone metabolites and their in vitro dual functions: they can act as an estrogenic agonist or antagonist depending on the estrogen concentration.
Hwang CS et al (2006) J Steroid Biochem Mol Biol 101(4-5) : 246-53.
Publications
These publications cite the use of Daidzein purchased from Hello Bio:
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Noradrenaline Modulates the Membrane Potential and Holding Current of Medial Prefrontal Cortex Pyramidal Neurons via β1-Adrenergic Receptors and HCN Channels.
Grzelka et al (2017) Grzelka et al 11:341 : 2PubMedID: 29209170
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