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Biological Data

Biological description Estrogen receptors (ER) agonist. Soy phytoestrogen and genistein analog. Also shows activity at PPARs. Shows both estrogenic/anti-estrogenic activity, induces apoptosis and anticancer effects. Active in vivo.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 7-Hydroxy-3-(4-hydroxyphenyl)-4H-1- benzopyran-4-one
Molecular Weight 254.24
Chemical structure Daidzein [486-66-8] Chemical Structure
Molecular Formula C15H10O4
CAS Number 486-66-8
PubChem identifier 5281708
SMILES C1=CC(=CC=C1C2=COC3=C(C2=O)C=CC(=C3)O)O
InChi InChI=1S/C15H10O4/c16-10-3-1-9(2-4-10)13-8-19-14-7-11(17)5-6-12(14)15(13)18/h1-8,16-17H
InChiKey ZQSIJRDFPHDXIC-UHFFFAOYSA-N
MDL number MFCD00016954

References for Daidzein

References are publications that support the biological activity of the product
  • Daidzein induced apoptosis via down-regulation of Bcl-2/Bax and triggering of the mitochondrial pathway in BGC-823 cells.

    Tang S et al (2013) Cell Biochem Biophys 65(2) : 197-202.
  • Daidzein causes cell cycle arrest at the G1 and G2/M phases in human breast cancer MCF-7 and MDA-MB-453 cells.

    Choi EJ et al (2008) Phytomedicine 15(9) : 683-90.
  • Isoflavone metabolites and their in vitro dual functions: they can act as an estrogenic agonist or antagonist depending on the estrogen concentration.

    Hwang CS et al (2006) J Steroid Biochem Mol Biol 101(4-5) : 246-53.
Publications
These publications cite the use of Daidzein purchased from Hello Bio:
  • Noradrenaline Modulates the Membrane Potential and Holding Current of Medial Prefrontal Cortex Pyramidal Neurons via β1-Adrenergic Receptors and HCN Channels.

    Grzelka et al (2017) Grzelka et al 11:341 : 2
    PubMedID: 29209170

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