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D-erythro-N,N-Dimethylsphingosine

(HB0237)
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Product overview

Name D-erythro-N,N-Dimethylsphingosine
Alternative names DMS
Purity >98%
Description Sphingosine kinase inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4)
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Biological Data

Biological description Competitive sphingosine kinase inhibitor (IC50 = 5 µM). Also inhibits protein kinase C (PKC). Shows cardioprotective, apoptotic and anti-cancer actions.

Solubility & Handling

Solubility overview Soluble in ethanol (25mg/ml) or DMSO (25mg/ml)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Molecular Weight 327.5
Chemical structure D-erythro-N,N-Dimethylsphingosine [119567-63-4] Chemical Structure
Molecular Formula C20H41NO2
CAS Number 119567-63-4
SMILES CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO)N(C)C

References for D-erythro-N,N-Dimethylsphingosine

References are publications that support the biological activity of the product

  • Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism.

    Jin ZQ et al (2006) Cardiovasc Res 71(4) : 725-34.
    Read more (PubMedID: 16831409)

  • D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells.

    Xu CB et al (2002) Atherosclerosis 164(2) : 237-43.
    Read more (PubMedID: 12204793)

  • Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines.

    Sweeney EA et al (1996) Int J Cancer 66(3) : 358-66.
    Read more (PubMedID: 8621258)

  • Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities.

    Igarashi Y et al (1989) Biochemistry 28(17) : 6796-800.
    Read more (PubMedID: 2479412)

4 Item(s)

Grouped product items
Order: HB0237
Pack PriceQty
100mg
$1,339
Sphingosine kinase inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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