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Biological Data Biological description Competitive sphingosine kinase inhibitor (IC50 = 5 µM). Also inhibits protein kinase C (PKC). Shows cardioprotective, apoptotic and anti-cancer actions.
Solubility & Handling Solubility overview Soluble in ethanol (25mg/ml) or DMSO (25mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical structure
Molecular Formula C20 H41 NO2
SMILES CCCCCCCCCCCCC/C=C/[C@@H](O)[C@H](CO)N(C)C
References for D-erythro-N,N-Dimethylsphingosine References are publications that support the biological activity of the product
Low dose N, N-dimethylsphingosine is cardioprotective and activates cytosolic sphingosine kinase by a PKCepsilon dependent mechanism. Jin ZQ et al (2006) Cardiovasc Res 71(4) : 725-34. D-erythro-N,N-dimethylsphingosine inhibits bFGF-induced proliferation of cerebral, aortic and coronary smooth muscle cells. Xu CB et al (2002) Atherosclerosis 164(2) : 237-43. Sphingosine and its methylated derivative N,N-dimethylsphingosine (DMS) induce apoptosis in a variety of human cancer cell lines. Sweeney EA et al (1996) Int J Cancer 66(3) : 358-66. Effect of chemically well-defined sphingosine and its N-methyl derivatives on protein kinase C and src kinase activities. Igarashi Y et al (1989) Biochemistry 28(17) : 6796-800.
Sphingosine kinase inhibitor
![D-erythro-N,N-Dimethylsphingosine [119567-63-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0237.png "D-erythro-N,N-Dimethylsphingosine [119567-63-4]")
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