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CP-91149

(HB0215)
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Product overview

Name CP-91149
Alternative names CP-91,149
Description Synthetic GP inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Synthetic glycogen phosphorylase (GP) inhibitor (IC50 = 0.5 µM). Approx 5-to 10- fold less potent in the absence of glucose. Also inhibits glucagon-stimulated glycogenolysis (IC50 = 2.1 µM) and activates glycogen synthase. Displays growth inhibitory properties.

Solubility & Handling

Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Chemical name 5-Chloro-N-[(1S,2R)-3-(dimethylamino)-2-hydroxy-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide
Molecular Weight 399.87
Chemical structure CP-91149 [186392-40-5] Chemical Structure
Molecular Formula C21H22ClN3O3
CAS Number 186392-40-5

References for CP-91149

References are publications that support the biological activity of the product

  • Inhibition of glycogen phosphorylase (GP) by CP-91,149 induces growth inhibition correlating with brain GP expression.

    Schnier JB et al (2003) Biochem Biophys Res Commun 309(1) : 126-34.
    Read more (PubMedID: 12943673)

  • Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: evidence from metabolic control analysis.

    Aiston S et al (2001) J Biol Chem 276(26) : 23858-66.
    Read more (PubMedID: 11309391)

  • Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo.

    Martin WH et al (1998) Proc Natl Acad Sci U S A 95(4) : 1776-81.
    Read more (PubMedID: 9465093)

3 Item(s)

Grouped product items
Order: HB0215
Pack PriceQty
10mg
$215
100mg
$1,738
Synthetic GP inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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