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Biological Data
| Biological description | Synthetic glycogen phosphorylase (GP) inhibitor (IC50 = 0.5 µM). Approx 5-to 10- fold less potent in the absence of glucose. Also inhibits glucagon-stimulated glycogenolysis (IC50 = 2.1 µM) and activates glycogen synthase. Displays growth inhibitory properties. |
Solubility & Handling
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 5-Chloro-N-[(1S,2R)-3-(dimethylamino)-2-hydroxy-3-oxo-1-(phenylmethyl)propyl]-1H-indole-2-carboxamide |
| Chemical structure | ![CP-91149 [186392-40-5] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "CP-91149 [186392-40-5]") |
| Molecular Formula | C21H22ClN3O3 |
References for CP-91149
References are publications that support the biological activity of the product
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Inhibition of glycogen phosphorylase (GP) by CP-91,149 induces growth inhibition correlating with brain GP expression.
Schnier JB et al (2003) Biochem Biophys Res Commun 309(1) : 126-34. -
Hepatic glycogen synthesis is highly sensitive to phosphorylase activity: evidence from metabolic control analysis.
Aiston S et al (2001) J Biol Chem 276(26) : 23858-66. -
Discovery of a human liver glycogen phosphorylase inhibitor that lowers blood glucose in vivo.
Martin WH et al (1998) Proc Natl Acad Sci U S A 95(4) : 1776-81.
![CP-91149 [186392-40-5] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0215.png "CP-91149 [186392-40-5]")
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