Product overview

Name Corticosterone
Description Endogenous gluococorticoid. MR and GR agonist.
Purity >99%
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Biological Data

Biological description Endogenous gluococorticoid. Acts as a mineralcorticoid (MR) and glucocorticoid receptor (GR) agonist. Involved in a wide range of biological processes and shows a variety of effects.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in DMSO (100 mM) and in ethanol (10 mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name (11β)-11,21-Dihydroxypregn-4-ene-3,2 0-dione
Molecular Weight 346.46
Chemical structure Corticosterone [50-22-6] Chemical Structure
Molecular Formula C21H30O4
CAS Number 50-22-6
PubChem identifier 5753
SMILES C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@H]2[C@H](C[C@]4([C@H]3CC[C@@H]4C(=O)CO)C)O
InChi InChI=1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1
InChiKey OMFXVFTZEKFJBZ-HJTSIMOOSA-N
MDL number MFCD00037715
Appearance White solid

References for Corticosterone

References are publications that support the biological activity of the product
  • Hippocampal corticosterone impairs memory consolidation during sleep but improves consolidation in the wake state.

    Kelemen E et al (2014) Hippocampus 24(5) : 510-5.
  • Corticosterone rapidly increases thorns of CA3 neurons via synaptic/extranuclear glucocorticoid receptor in rat hippocampus.

    Yoshiya M et al (2013) Front Neural Circuits 7 : 191
  • Corticosterone acts in the nucleus accumbens to enhance dopamine signaling and potentiate reinstatement of cocaine seeking.

    Graf EN et al (2013) J Neurosci 33(29) : 11800-10.