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Images Co 102862 product vial image | Hello Bio
Co 102862 product vial image | Hello Bio Biological Data Biological description Potent voltage-gated Na+ channel blocker. Shows greater affinity for inactive (Ki = 0.4 µM) compared to resting state Nav 1.2 channels (Kr = 30 µM). Shows anticonvulsant and potential analgesic actions.
Solubility & Handling Storage instructions Room temperature
Solubility overview Soluble in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name 2-[[4-(4-Fluorophenoxy)phenyl]methylene]hydrazinecarboxamide
Chemical structure
Molecular Formula C14 H12 FN3 O2
PubChem identifier 9816959
SMILES NC(=O)N\N=C\C1=CC=C(OC2=CC=C(F)C=C2)C=C1
InChiKey MHUUDVZSPFRUSK-RQZCQDPDSA-N
References for Co 102862 References are publications that support the biological activity of the product
Functional and pharmacological properties of human and rat NaV1.8 channels. Browne LE et al (2009) Neuropharmacology 56(5) : 905-14. Pharmacology of 2-[4-(4-chloro-2-fluorophenoxy)phenyl]-pyrimidine-4-carboxamide: a potent, broad-spectrum state-dependent sodium channel blocker for treating pain states. Ilyin VI et al (2006) J Pharmacol Exp Ther 318(3) : 1083-93. V102862 (Co 102862): a potent, broad-spectrum state-dependent blocker of mammalian voltage-gated sodium channels. Ilyin VI et al (2005) Br J Pharmacol 144(6) : 801-12.
Potent voltage-gated Na+ channel blocker
![Co 102862 [181144-66-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1013.png "Co 102862 [181144-66-1]")
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