Product overview

Name CMIQ
Purity >95%
Description Potent, selective PKA inhibitor
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Biological Data

Biological description Potent and selective protein kinase A (PKA) inhibitor (IC50 = 30 nM ). Membrane permeable. Blocks ATP-binding site of PKA. Restores morphine-related behaviours in morphine tolerance.

Solubility & Handling

Solubility overview Soluble in DMSO (50mg/ml)
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Purity >95%
Chemical name PKA Inhibitor XI
Molecular Weight 168.2
Chemical structure CMIQ  [161468-32-2] Chemical Structure
Molecular Formula C11H8N2
CAS Number 161468-32-2

References for CMIQ

References are publications that support the biological activity of the product
  • PKC and PKA inhibitors reinstate morphine-induced behaviors in morphine tolerant mice.

    Smith FL et al (2006) Pharmacol Res 54(6) : 474-80.
  • Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism.

    Hucho TB et al (2005) J Neurosci 25(26) : 6119-26.
  • Selective inhibition of cyclic AMP-dependent protein kinase by isoquinoline derivatives.

    Lu ZX et al (1996) Biol Chem Hoppe Seyler 377(6) : 373-84.

3 Item(s)