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Biological Data

Biological description Potent and selective protein kinase A (PKA) inhibitor (IC50 = 30 nM ). Membrane permeable. Blocks ATP-binding site of PKA. Restores morphine-related behaviours in morphine tolerance.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (50mg/ml)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >95%
Chemical name PKA Inhibitor XI
Molecular Weight 168.2
Chemical structure CMIQ  [161468-32-2] Chemical Structure
Molecular Formula C11H8N2
CAS Number 161468-32-2

References for CMIQ

References are publications that support the biological activity of the product
  • PKC and PKA inhibitors reinstate morphine-induced behaviors in morphine tolerant mice.

    Smith FL et al (2006) Pharmacol Res 54(6) : 474-80.
  • Epac mediates a cAMP-to-PKC signaling in inflammatory pain: an isolectin B4(+) neuron-specific mechanism.

    Hucho TB et al (2005) J Neurosci 25(26) : 6119-26.
  • Selective inhibition of cyclic AMP-dependent protein kinase by isoquinoline derivatives.

    Lu ZX et al (1996) Biol Chem Hoppe Seyler 377(6) : 373-84.

3 Item(s)