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Biological Data
| Biological description | Potent L- and N-type calcium channel blocker (IC50 values are 100 and 200 nM). Inhibits sympathetic neurotransmitter release via N-type Ca2+ channel block. Shows antihypertensive, cardioprotective, renoprotective and neuroprotective actions. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in DMSO (100mM) or ethanol (10mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 2-methoxyethyl(2E)-3-phenyl-2-propenyl ester |
| Chemical structure | ![Cilnidipine [132203-70-4] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Cilnidipine [132203-70-4]") |
| Molecular Formula | C27H28N2O7 |
| SMILES | COCCOC(=O)C1=C(C)NC(C)=C(C1C1=CC=CC(=C1)[N+]([O-])=O)C(=O)OCC=CC1=CC=CC=C1 |
| InChiKey | KJEBULYHNRNJTE-UHFFFAOYSA-N |
References for Cilnidipine
References are publications that support the biological activity of the product
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Cilnidipine: a new generation Ca channel blocker with inhibitory action on sympathetic neurotransmitter release.
Takahara A (2009) Cardiovasc Ther 27(2) : 124-39. -
Neuroprotective effects of a dual L/N-type Ca(2+) channel blocker cilnidipine in the rat focal brain ischemia model.
Takahara A et al (2004) Biol Pharm Bull 27(9) : 1388-91. -
Effect of cilnidipine, a novel dihydropyridine Ca++-channel antagonist, on N-type Ca++ channel in rat dorsal root ganglion neurons.
Fujii S et al (1997) J Pharmacol Exp Ther 280(3) : 1184-91.
Potent L- / N-type calcium channel blocker
![Cilnidipine [132203-70-4] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1217.png "Cilnidipine [132203-70-4]")
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