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Biological Data

Biological description Kv7.1 channel blocker (also known as the slow delayed rectifier or IKs channel). Blocks the K+ current (IC50 = 1.8 µM). Selective for the KCNQ1 subunit combined with KCNE3 over KCNE1 (IC50 values are 0.54 and 15.1 µM respectively). Also blocks the CFTR chloride current (ICFTR) and Kv4.3 channel Ito transient outward current (IC50 values are 19 and 38 µM respectively).

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in ethanol (20mM) or DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Purity >99%
Chemical name trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide
Molecular Weight 324.39
Chemical structure Chromanol 293B  [163163-23-3] Chemical Structure
Molecular Formula C15H20N2O4S
CAS Number 163163-23-3
PubChem identifier 6483057
SMILES O[C@H]1[C@H](N(C)S(=O)(CC)=O)C2=C(C=CC(C#N)=C2)OC(C)1C.O[C@@H]3[C@@H](N(C)S(=O)(CC)=O)C4=C(C=CC(C#N)=C4)OC(C)3C

References for Chromanol 293B

References are publications that support the biological activity of the product
  • Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel.

    Bett GC et al (2006) J Physiol 576(Pt 3) : 755-67.
  • Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes.

    Sun ZQ et al (2001) J Cardiovasc Electrophysiol 12(4) : 472-8.
  • Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKs), inhibits the CFTR Cl- current.

    Bachmann A et al (2001) Naunyn Schmiedebergs Arch Pharmacol 363(6) : 590-6.

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