Product overview
| Name | Chromanol 293B |
| Description | Kv7.1 channel blocker |
| Purity | >99% |
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Biological Data
| Biological description | Kv7.1 channel blocker (also known as the slow delayed rectifier or IKs channel). Blocks the K+ current (IC50 = 1.8 µM). Selective for the KCNQ1 subunit combined with KCNE3 over KCNE1 (IC50 values are 0.54 and 15.1 µM respectively). Also blocks the CFTR chloride current (ICFTR) and Kv4.3 channel Ito transient outward current (IC50 values are 19 and 38 µM respectively). |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in ethanol (20mM) or DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | trans-N-[6-Cyano-3,4-dihydro-3-hydroxy-2,2-dimethyl-2H-1-benzopyran-4-yl]-N-methyl-ethanesulfonamide |
| Molecular Weight | 324.39 |
| Chemical structure | ![Chromanol 293B [163163-23-3] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0988.png "Chromanol 293B [163163-23-3]") |
| Molecular Formula | C15H20N2O4S |
| CAS Number | 163163-23-3 |
| PubChem identifier | 6483057 |
| SMILES | O[C@H]1[C@H](N(C)S(=O)(CC)=O)C2=C(C=CC(C#N)=C2)OC(C)1C.O[C@@H]3[C@@H](N(C)S(=O)(CC)=O)C4=C(C=CC(C#N)=C4)OC(C)3C |
| InChiKey | CUJUUWXZAQHCNC-DOFZRALJSA-N |
References for Chromanol 293B
References are publications that support the biological activity of the product
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Ancillary subunits and stimulation frequency determine the potency of chromanol 293B block of the KCNQ1 potassium channel.
Bett GC et al (2006) J Physiol 576(Pt 3) : 755-67. -
Chromanol 293B inhibits slowly activating delayed rectifier and transient outward currents in canine left ventricular myocytes.
Sun ZQ et al (2001) J Cardiovasc Electrophysiol 12(4) : 472-8. -
Chromanol 293B, a blocker of the slow delayed rectifier K+ current (IKs), inhibits the CFTR Cl- current.
Bachmann A et al (2001) Naunyn Schmiedebergs Arch Pharmacol 363(6) : 590-6.
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