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Chaetocin

(HB1415)
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Product overview

Name Chaetocin
Purity >99%
Description Potent histone methyltransferase SUV39H1 inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4) Frequently bought together
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Biological Data

Biological description Potent histone methyltransferase SUV39H1 inhibitor (IC50 = 0.8 µM). Induces reactive oxygen species. Shows apoptotic and anti-cancer actions.

Solubility & Handling

Solubility overview Soluble in DMSO (10mM)
Storage instructions -20°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name (3S,3'S,5aR,5aR,10bR,10'bR,11aS,11'aS) -2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl )-2,2'-dimethyl-[10b,10'b(11H,11'H)-bi3,11a-epidithio -11aH-pyrazino[1',2':1,5]pyrrolo[2,3-b]indole]-1,1',4 ,4'-tetrone
Molecular Weight 696.84
Chemical structure Chaetocin [28097-03-2] Chemical Structure
Molecular Formula C30H28N6O6S4
CAS Number 28097-03-2
PubChem identifier 161591
SMILES CN(C([C@]35N1[C@@]2([H])NC4=C(C=CC=C4)[C@]([C@@]68C(C=CC=C9)=C9N[C@@]([H])6N7[C@@](C8)%10C(N(C)[C@@](CO)(SS%10)C7=O)=O)2C3)=O)[C@@](CO)(SS5)C1=O
InChiKey PZPPOCZWRGNKIR-UHFFFAOYSA-N

References for Chaetocin

References are publications that support the biological activity of the product

  • Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism.

    Dixit D et al (2014) Cell Death Dis 5 : e1212.
    Read more (PubMedID: 24810048)

  • Reply to 'Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases'.

    Greiner D et al (2013) Nat Chem Biol 9(3) : 137
    Read more (PubMedID: 23416388)

  • Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases.

    Cherblanc FL et al (2013) Nat Chem Biol 9(3) : 136-7.
    Read more (PubMedID: 23416387)

  • The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation.

    Isham CR et al (2012) Br J Cancer 106(2) : 314-23.
    Read more (PubMedID: 22187030)

4 Item(s)

Grouped product items
Order: HB1415
Pack PriceQty
1mg
$226
5mg
$912
Potent histone methyltransferase SUV39H1 inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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