The store will not work correctly in the case when cookies are disabled.
JavaScript seems to be disabled in your browser. For the best experience on our site, be sure to turn on Javascript in your browser.
Biological Data Biological description Potent histone methyltransferase SUV39H1 inhibitor (IC50 = 0.8 µM). Induces reactive oxygen species. Shows apoptotic and anti-cancer actions.
Solubility & Handling Storage instructions -20°C
Solubility overview Soluble in DMSO (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (3S ,3'S ,5aR ,5aR ,10bR ,10'bR ,11aS ,11'aS ) -2,2',3,3',5a,5'a,6,6'-octahydro-3,3'-bis(hydroxymethyl )-2,2'-dimethyl-[10b,10'b(11H ,11'H )-bi3,11a-epidithio -11aH -pyrazino[1',2':1,5]pyrrolo[2,3-b ]indole]-1,1',4 ,4'-tetrone
Chemical structure
Molecular Formula C30 H28 N6 O6 S4
PubChem identifier 161591
SMILES CN(C([C@]35N1[C@@]2([H])NC4=C(C=CC=C4)[C@]([C@@]68C(C=CC=C9)=C9N[C@@]([H])6N7[C@@](C8)%10C(N(C)[C@@](CO)(SS%10)C7=O)=O)2C3)=O)[C@@](CO)(SS5)C1=O
InChiKey PZPPOCZWRGNKIR-UHFFFAOYSA-N
References for Chaetocin References are publications that support the biological activity of the product
Chaetocin-induced ROS-mediated apoptosis involves ATM-YAP1 axis and JNK-dependent inhibition of glucose metabolism. Dixit D et al (2014) Cell Death Dis 5 : e1212. Reply to 'Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases'. Greiner D et al (2013) Nat Chem Biol 9(3) : 137 Chaetocin is a nonspecific inhibitor of histone lysine methyltransferases. Cherblanc FL et al (2013) Nat Chem Biol 9(3) : 136-7. The anticancer effects of chaetocin are independent of programmed cell death and hypoxia, and are associated with inhibition of endothelial cell proliferation. Isham CR et al (2012) Br J Cancer 106(2) : 314-23.
Potent histone methyltransferase SUV39H1 inhibitor
![Chaetocin [28097-03-2] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1415.png "Chaetocin [28097-03-2]")
Understanding purity and quality - a guide for life scientists