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Biological Data

Biological description Selective CDK1 inhibitor. Shows anti-tumor activity, induces apoptosis and mitochondrial damage.

Solubility & Handling

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name 2-N-(2-aminocyclohexyl)-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamine
Molecular Weight 385.89
Chemical structure CGP 74514A Chemical Structure
Molecular Formula C19H24ClN7
CAS Number 1173021-98-1
PubChem identifier 4644095
SMILES CCN1C=NC2=C1N=C(N=C2NC3=CC(=CC=C3)Cl)NC4CCCCC4N

References for CGP 74514A

References are publications that support the biological activity of the product
  • The cytotoxic effect of emetine and CGP-74514A studied with the hollow fiber model and ArrayScan assay in neuroendocrine tumors in vitro.

    Larsson DE et al (2012) Anticancer Agents Med Chem 12(7) : 783-90.
  • CDK1 differentially regulates G-overhang generation at leading- and lagging-strand telomeres in telomerase-negative cells in G2 phase.

    Dai X et al (2012) Cell Cycle 11(16) : 3079-86.
  • Induction of apoptosis in human leukemia cells by the CDK1 inhibitor CGP74514A.

    Dai Y et al (2002) Cell Cycle 1(2) : 143-52.