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Biological Data
| Biological description | Selective CDK1 inhibitor. Shows anti-tumor activity, induces apoptosis and mitochondrial damage. |
Solubility & Handling
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 2-N-(2-aminocyclohexyl)-6-N-(3-chlorophenyl)-9-ethylpurine-2,6-diamine |
| Chemical structure |  |
| Molecular Formula | C19H24ClN7 |
| PubChem identifier | 4644095 |
| SMILES | CCN1C=NC2=C1N=C(N=C2NC3=CC(=CC=C3)Cl)NC4CCCCC4N |
References for CGP 74514A
References are publications that support the biological activity of the product
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The cytotoxic effect of emetine and CGP-74514A studied with the hollow fiber model and ArrayScan assay in neuroendocrine tumors in vitro.
Larsson DE et al (2012) Anticancer Agents Med Chem 12(7) : 783-90. -
CDK1 differentially regulates G-overhang generation at leading- and lagging-strand telomeres in telomerase-negative cells in G2 phase.
Dai X et al (2012) Cell Cycle 11(16) : 3079-86. -
Induction of apoptosis in human leukemia cells by the CDK1 inhibitor CGP74514A.
Dai Y et al (2002) Cell Cycle 1(2) : 143-52.
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