The store will not work correctly in the case when cookies are disabled.
Biological Data
| Biological description | Potent and selective protein phosphatase 2A (PP2A) inhibitor (IC50 = 53 nM). Selective for PP2A over PP1 (IC50 = 562 nM). Potentiates cyclic-AMP Response element binding (CREB) signalling (EC50 = 0.45 µM). Increases transduction of adenovirus vectors. Shows apoptotic actions. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in DMSO (100 mM) and in ethanol (25 mM, gentle warming) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 2,3-Dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid |
| Molecular Formula | C10H14O5 |
| PubChem identifier | 121475 |
| SMILES | C[C@]1([C@H]2CC[C@@H]([C@]1(C)C(=O)O)O2)C(=O)O |
| InChi | InChI=1S/C10H14O5/c1-9(7(11)12)5-3-4-6(15-5)10(9,2)8(13)14/h5-6H,3-4H2,1-2H3,(H,11,12)(H,13,14)/t5-,6+,9+,10- |
| InChiKey | NMTNUQBORQILRK-XCVPVQRUSA-N |
References for Cantharidic Acid
References are publications that support the biological activity of the product
-
Suppression of protein phosphatase 2A activity enhances Ad5/F35 adenovirus transduction efficiency in normal human B lymphocytes and in Raji cells.
Cayer MP et al (2012) J Immunol Methods 376(1-2) : 113-24. -
Identification of compounds that potentiate CREB signaling as possible enhancers of long-term memory.
Xia M et al (2009) Proc Natl Acad Sci U S A 106(7) : 2412-7. -
Structure activity analysis of the pro-apoptotic, antitumor effect of nitrostyrene adducts and related compounds.
Kaap S et al (2003) Biochem Pharmacol 65(4) : 603-10.
Potent, selective PP2A inhibitor
Understanding purity and quality - a guide for life scientists