Product overview

Name cAMPS-Rp, triethylammonium salt
Description cAMP antagonist
Purity >98%
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Biological Data

Biological description cAMP analog. Antagonises cAMP cell surface receptor, type I and II protein kinases. Competitive antagonist of c-AMP-induced PKA activation (IC50. Inhibits pain-related synaptic plasticity in amygdala brain tissue. Cell permeable.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



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Chemical Data

Chemical name (R)-Adenosine,cyclic3',5'-(hydrogenphosphorothioate)triethylammonium
Molecular Weight 446.46
Molecular Formula C10H12N5O5PS.C6H15N
CAS Number 151837-09-1
PubChem identifier 5311365
SMILES [H][C@@]([C@@](O[C@@H](N3C=NC4=C3N=CN=C4N)[C@@H]2O)([H])CO1)2O[P@@]1([S-])=O.CC[NH+](CC)CC

References for cAMPS-Rp, triethylammonium salt

References are publications that support the biological activity of the product
  • PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior.

    Fu Y et al (2008) Mol Pain 4 : 26
  • Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates.

    Dostmann WR et al (1990) J Biol Chem 265(18) : 10484-91.
  • Competitive cAMP antagonists for cAMP-receptor proteins.

    Van Haastert PJ et al (1984) J Biol Chem 259(16) : 10020-4.