Product overview
| Name | cAMPS-Rp, triethylammonium salt |
| Description | cAMP antagonist |
| Purity | >98% |
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Biological Data
| Biological description | cAMP analog. Antagonises cAMP cell surface receptor, type I and II protein kinases. Competitive antagonist of c-AMP-induced PKA activation (IC50. Inhibits pain-related synaptic plasticity in amygdala brain tissue. Cell permeable. |
Solubility & Handling
| Storage instructions | -20°C (desiccate) |
| Solubility overview | Soluble in water (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | (R)-Adenosine,cyclic3',5'-(hydrogenphosphorothioate)triethylammonium |
| Molecular Weight | 446.46 |
| Molecular Formula | C10H12N5O5PS.C6H15N |
| CAS Number | 151837-09-1 |
| PubChem identifier | 5311365 |
| SMILES | [H][C@@]([C@@](O[C@@H](N3C=NC4=C3N=CN=C4N)[C@@H]2O)([H])CO1)2O[P@@]1([S-])=O.CC[NH+](CC)CC |
| InChiKey | FKAWLXNLHHIHLA-YCBIHMBMSA-N |
References for cAMPS-Rp, triethylammonium salt
References are publications that support the biological activity of the product
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PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior.
Fu Y et al (2008) Mol Pain 4 : 26 -
Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates.
Dostmann WR et al (1990) J Biol Chem 265(18) : 10484-91. -
Competitive cAMP antagonists for cAMP-receptor proteins.
Van Haastert PJ et al (1984) J Biol Chem 259(16) : 10020-4.
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