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cAMPS-Rp, triethylammonium salt

(HB0165)
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Product overview

Name cAMPS-Rp, triethylammonium salt
Purity >98%
Description cAMP antagonist
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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Biological Data

Biological description cAMP analog. Antagonises cAMP cell surface receptor, type I and II protein kinases. Competitive antagonist of c-AMP-induced PKA activation (IC50. Inhibits pain-related synaptic plasticity in amygdala brain tissue. Cell permeable.

Solubility & Handling

Storage instructions -20°C (desiccate)
Solubility overview Soluble in water (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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More Info

Dilution

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Chemical Data

Purity >98%
Chemical name (R)-Adenosine,cyclic3',5'-(hydrogenphosphorothioate)triethylammonium
Molecular Weight 446.46
Molecular Formula C10H12N5O5PS.C6H15N
CAS Number 151837-09-1
PubChem identifier 5311365
SMILES [H][C@@]([C@@](O[C@@H](N3C=NC4=C3N=CN=C4N)[C@@H]2O)([H])CO1)2O[P@@]1([S-])=O.CC[NH+](CC)CC
InChiKey FKAWLXNLHHIHLA-YCBIHMBMSA-N

References for cAMPS-Rp, triethylammonium salt

References are publications that support the biological activity of the product

  • PKA and ERK, but not PKC, in the amygdala contribute to pain-related synaptic plasticity and behavior.

    Fu Y et al (2008) Mol Pain 4 : 26
    Read more (PubMedID: 18631385)

  • Probing the cyclic nucleotide binding sites of cAMP-dependent protein kinases I and II with analogs of adenosine 3',5'-cyclic phosphorothioates.

    Dostmann WR et al (1990) J Biol Chem 265(18) : 10484-91.
    Read more (PubMedID: 2162349)

  • Competitive cAMP antagonists for cAMP-receptor proteins.

    Van Haastert PJ et al (1984) J Biol Chem 259(16) : 10020-4.
    Read more (PubMedID: 6088478)

3 Item(s)

Grouped product items
Order: HB0165
Pack PriceQty
1mg
$179
cAMP antagonist
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