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Biological Data

Biological description Non-competitive irreversible protein tyrosine phosphatases (PTP) inhibitor (Ki = 1.2 µM for PTP-1B). Inhibits a broad spectrum of PTP's (IC50 values are 0.9, 1.7, 0.09, 1.5 and 0.7 µM for PTP-1B, TCPTP, SHP-2, LAR and YopH respectively). Inhibits several cytochrome P450 isoforms and suppresses MMP-9 and blocks TPA-induced NF-κB activation. Exhibits no activity for MAPK. Enhances insulin sensitivity. Cell permeable.

Solubility & Handling

Storage instructions Room temperature
Solubility overview Soluble in ethanol or DMSO (50mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Molecular Weight 241.25
Chemical structure BVT 948  [39674-97-0] Chemical Structure
Molecular Formula C14H11NO3
CAS Number 39674-97-0
PubChem identifier 6604934
SMILES CC1(C2=C(C3=CC=CC=C3C(=O)C2=O)NC1=O)C
InChiKey LLPBUXODFQZPFH-UHFFFAOYSA-N

References for BVT 948

References are publications that support the biological activity of the product
  • Protein tyrosine phosphatase controls breast cancer invasion through the expression of matrix metalloproteinase-9.

    Hwang BM et al (2013) BMB Rep 46(11) : 533-8.
  • Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione.

    Liljebris C et al (2004) J Pharmacol Exp Ther 309(2) : 711-9.