Non-competitive irreversible protein tyrosine phosphatases (PTP) inhibitor (Ki = 1.2 µM for PTP-1B). Inhibits a broad spectrum of PTP's (IC50 values are 0.9, 1.7, 0.09, 1.5 and 0.7 µM for PTP-1B, TCPTP, SHP-2, LAR and YopH respectively). Inhibits several cytochrome P450 isoforms and suppresses MMP-9 and blocks TPA-induced NF-κB activation. Exhibits no activity for MAPK. Enhances insulin sensitivity. Cell permeable.
Solubility & Handling
Soluble in ethanol or DMSO (50mM)
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.