Non-competitive irreversible protein tyrosine phosphatases (PTP) inhibitor (Ki = 1.2 µM for PTP-1B). Inhibits a broad spectrum of PTP's (IC50 values are 0.9, 1.7, 0.09, 1.5 and 0.7 µM for PTP-1B, TCPTP, SHP-2, LAR and YopH respectively). Inhibits several cytochrome P450 isoforms and suppresses MMP-9 and blocks TPA-induced NF-κB activation. Exhibits no activity for MAPK. Enhances insulin sensitivity. Cell permeable.
Solubility & Handling
Solubility overview
Soluble in ethanol or DMSO (50mM)
Storage instructions
Room temperature
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione.
Liljebris C et al (2004) J Pharmacol Exp Ther 309(2) : 711-9.
![BVT 948 [39674-97-0] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb0150.png "BVT 948 [39674-97-0]")
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