Product overview

Name Butyrolactone I
Purity >97%
Description Potent, selective CDK1, CDK2 and CDK5 inhibitor
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Biological Data

Biological description Cell permeable, potent and selective cyclin-dependent kinase CDK-1 (CDC2), -2 and -5 inhibitor. Apoptosis inducer. Antitumor agent. Inhibits cell cycle progression at the G1/S and G2/M transitions. Shown to prevent the phosphorylation of retinoblastoma protein and H1 histone. Important probe for understanding the cellular roles of CDKs.

Solubility & Handling

Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Chemical Data

Purity >97%
Molecular Weight 424.5
Chemical structure Butyrolactone I [87414-49-1] Chemical Structure
CAS Number 87414-49-1
SMILES CC(C)=CCc1cc(COC(=O)[C@]2(C)OC(=O)C(=C2c3ccc(O)cc3)O)ccc1O
InChiKey NGOLMNWQNHWEKU-UHFFFAOYSA-N
Appearance White to off-white solid