bpV(pic)

Name: bpV(pic)
SKU: HB0147
Price: 304 USD
Availability: InStock

(HB0147)

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Technical documents: Datasheet

Product overview

Name

bpV(pic)

Purity

>90%

Description

Potent PTP inhibitor

Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) References (4)

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Biological Data

Biological description

Potent protein phosphotyrosine phosphatase (PTP) inhibitor (IC₅₀ values are 12.7 and 61 µM for PTP-β and PTP-1B respectively). Also inhibits phosphatase and tensin homologue (PTEN) (IC₅₀ = 31 nM) and activates insulin-receptor kinase (IRK). Displays cardioprotective and insulin-mimetic properties.

Solubility & Handling

Storage instructions

+4°C

Solubility overview

Soluble in water or DMSO

Important

This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

More Info

Dilution

More Info

Chemical Data

Purity

>90%

Chemical name

Dipotassium bisperoxo (picolinato)oxovanadate (V)

Molecular Weight

367.28

Chemical structure

Molecular Formula

K₂ [VO(O₂)₂C₆H₄NO₂].2H₂O

CAS Number

148556-27-8

PubChem identifier

16760324

SMILES

C1=CC=NC(=C1)C(=O)[O-].O.O.[OH-].OO.OO.[K+].[K+].[V]

Technical guides

Understanding purity and quality - a guide for life scientists (159.4 KB)

References for bpV(pic)

References are publications that support the biological activity of the product

Effects of bpV(pic) and bpV(phen) on H9c2 cardiomyoblasts during both hypoxia/reoxygenation and H2O2-induced injuries.
Tian Y et al (2012) Mol Med Rep 5(3) : 852-8.
Read more (PubMedID: 22200881)
Bisperoxovanadium compounds are potent PTEN inhibitors.
Schmid AC et al (2004) FEBS Lett 566(1-3) : 35-8.
Read more (PubMedID: 15147864)
Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen).
Band CJ et al (1997) Mol Endocrinol 11(13) : 1899-910.
Read more (PubMedID: 9415395)
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.
Posner BI et al (1994) J Biol Chem 269(6) : 4596-604.
Read more (PubMedID: 8308031)

Potent PTP inhibitor

Order: HB0147
Pack	Price	Qty
25mg	$304

bpV(pic)

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for bpV(pic)

Effects of bpV(pic) and bpV(phen) on H9c2 cardiomyoblasts during both hypoxia/reoxygenation and H2O2-induced injuries.

Bisperoxovanadium compounds are potent PTEN inhibitors.

Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen).

Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.

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bpV(pic)

Product overview

Biological Data

Solubility & Handling

Calculators

Molarity

Dilution

Chemical Data

Technical guides

References for bpV(pic)

Effects of bpV(pic) and bpV(phen) on H9c2 cardiomyoblasts during both hypoxia/reoxygenation and H2O2-induced injuries.

Bisperoxovanadium compounds are potent PTEN inhibitors.

Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen).

Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.

About you

Tell us about your publication!

Captcha

About you

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New Products in this Area