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Biological Data

Biological description Potent protein phosphotyrosine phosphatase (PTP) inhibitor (IC50 values are 18 and 164 nM for PTP-β and PTP-1B respectively). Also inhibits phosphatase and tensin homologue (PTEN) (IC50 = 18 nM). Displays insulin-mimetic properties.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in water
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name Potassiumbisperoxo(bipyridine)oxovanadate(V)
Molecular Weight 326.2
Chemical structure bpV(bipy) Chemical Structure
Molecular Formula K[VO(O2)2C10H8N2]
CAS Number 127393-89-9
SMILES C[C@@H]1C[C@H](O)\C=C/[C@H](O)[C@@H](O)CC(=O)O1

References for bpV(bipy)

References are publications that support the biological activity of the product
  • Bisperoxovanadium compounds are potent PTEN inhibitors.

    Schmid AC et al (2004) FEBS Lett 566(1-3) : 35-8.
  • Inhibition Effects of Some Bioactive Peroxovanadium Complexes on the Tyrosine Phosphatase.

    Zhou XW et al (2000) Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 32(2) : 133-138.
  • Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen).

    Band CJ et al (1997) Mol Endocrinol 11(13) : 1899-910.
  • Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.

    Posner BI et al (1994) J Biol Chem 269(6) : 4596-604.