Product overview
| Name | bpV(bipy) |
| Description | Potent protein PTP inhibitor |
| Purity | >95% |
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Biological Data
| Biological description | Potent protein phosphotyrosine phosphatase (PTP) inhibitor (IC50 values are 18 and 164 nM for PTP-β and PTP-1B respectively). Also inhibits phosphatase and tensin homologue (PTEN) (IC50 = 18 nM). Displays insulin-mimetic properties. |
Solubility & Handling
| Storage instructions | +4°C |
| Solubility overview | Soluble in water |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | Potassiumbisperoxo(bipyridine)oxovanadate(V) |
| Molecular Weight | 326.2 |
| Chemical structure |  |
| Molecular Formula | K[VO(O2)2C10H8N2] |
| CAS Number | 127393-89-9 |
| SMILES | C[C@@H]1C[C@H](O)\C=C/[C@H](O)[C@@H](O)CC(=O)O1 |
References for bpV(bipy)
References are publications that support the biological activity of the product
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Bisperoxovanadium compounds are potent PTEN inhibitors.
Schmid AC et al (2004) FEBS Lett 566(1-3) : 35-8. -
Inhibition Effects of Some Bioactive Peroxovanadium Complexes on the Tyrosine Phosphatase.
Zhou XW et al (2000) Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 32(2) : 133-138. -
Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen).
Band CJ et al (1997) Mol Endocrinol 11(13) : 1899-910. -
Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.
Posner BI et al (1994) J Biol Chem 269(6) : 4596-604.
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