Potent protein phosphotyrosine phosphatase (PTP) inhibitor (IC50 values are 18 and 164 nM for PTP-β and PTP-1B respectively). Also inhibits phosphatase and tensin homologue (PTEN) (IC50 = 18 nM). Displays insulin-mimetic properties.
Solubility & Handling
Solubility overview
Soluble in water
Storage instructions
+4°C
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen).
Band CJ et al (1997) Mol Endocrinol 11(13) : 1899-910.
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