Product overview

Name bpV(bipy)
Purity >95%
Description Potent protein PTP inhibitor
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Biological Data

Biological description Potent protein phosphotyrosine phosphatase (PTP) inhibitor (IC50 values are 18 and 164 nM for PTP-β and PTP-1B respectively). Also inhibits phosphatase and tensin homologue (PTEN) (IC50 = 18 nM). Displays insulin-mimetic properties.

Solubility & Handling

Solubility overview Soluble in water
Storage instructions +4°C
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >95%
Chemical name Potassiumbisperoxo(bipyridine)oxovanadate(V)
Molecular Weight 326.2
Chemical structure bpV(bipy) Chemical Structure
Molecular Formula K[VO(O2)2C10H8N2]
CAS Number 127393-89-9
SMILES C[C@@H]1C[C@H](O)\C=C/[C@H](O)[C@@H](O)CC(=O)O1

References for bpV(bipy)

References are publications that support the biological activity of the product
  • Bisperoxovanadium compounds are potent PTEN inhibitors.

    Schmid AC et al (2004) FEBS Lett 566(1-3) : 35-8.
  • Inhibition Effects of Some Bioactive Peroxovanadium Complexes on the Tyrosine Phosphatase.

    Zhou XW et al (2000) Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai) 32(2) : 133-138.
  • Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen).

    Band CJ et al (1997) Mol Endocrinol 11(13) : 1899-910.
  • Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.

    Posner BI et al (1994) J Biol Chem 269(6) : 4596-604.

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