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Bosutinib

(HB1323)
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Product overview

Name Bosutinib
Alternative names SKI-606
Purity >99%
Description Abl / Src kinase inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (2) Frequently bought together
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Biological Data

Biological description Abl and Src kinase inhibitor (IC50 values are 1.2 and 2.4 nM for Src and Abl respectively). Selective for Src family kinases. Shows actions against chronic myeloid leukemia (CML). Shows antiproliferative and anti-tumor actions.

Solubility & Handling

Storage instructions +4°C
Solubility overview Soluble in DMSO (100mM) or ethanol (25mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propoxy]-3-quinolinecarbonitrile
Molecular Weight 530.45
Molecular Formula C26H29Cl2N5O3
CAS Number 380843-75-4
PubChem identifier 5328940
SMILES ClC1=CC(Cl)=C(OC)C=C1NC3=C(C#N)C=NC2=CC(OCCCN4CCN(C)CC4)=C(OC)C=C23
InChiKey UBPYILGKFZZVDX-UHFFFAOYSA-N

References for Bosutinib

References are publications that support the biological activity of the product

  • Profile of bosutinib and its clinical potential in the treatment of chronic myeloid leukemia.

    Amsberg GK et al (2013) Onco Targets Ther 6 : 99-106.
    Read more (PubMedID: 23493838)

  • Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity.

    Boschelli DH et al (2001) J Med Chem 44(23) : 3965-77.
    Read more (PubMedID: 11689083)

2 Item(s)

Grouped product items
Order: HB1323
Pack PriceQty
5mg
$165
10mg
$244
50mg
$974
Abl / Src kinase inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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