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Biological Data Biological description Potent KCa 1.1 channel activator. Displays vasodilation and neuroprotective properties. Blood brain barrier permeable.
Solubility & Handling Solubility overview Soluble in DMSO (100mM) or ethanol (15mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use
Chemical Data Chemical name 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2( 3H )-one
Chemical structure
Molecular Formula C16 H10 ClF3 N2 O3
PubChem identifier 10474339
SMILES OC1=CC=C(Cl)C=C1CN1N=C(OC1=O)C1=CC=C(C=C1)C(F)(F)F
InChi InChI=1S/C16H10ClF3N2O3/c17-12-5-6-13(23)10(7-12)8-22-15(24)25-14(21-22)9-1-3-11(4-2-9)16(18,19)20/h1-7,23H,8H2
InChiKey QKOWACXSXTXRKA-UHFFFAOYSA-N
References for BMS 191011 References are publications that support the biological activity of the product
BMS-191011, an opener of large-conductance Ca2+-activated potassium channels, dilates rat retinal arterioles in vivo. Mori A et al (2011) Biol Pharm Bull 34(1) : 150-2. 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR. Romine JL et al (2007) J Med Chem 50(3) : 528-42. Synthesis of water-soluble prodrugs of BMS-191011: a maxi-K channel opener targeted for post-stroke neuroprotection. Hewawasam P et al (2003) Bioorg Med Chem Lett 13(10) : 1695-8.
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Potent KCa 1.1 channel activator