Product overview

Name BMS 191011
Purity >95%
Description Potent KCa1.1 channel activator
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Biological Data

Biological description Potent KCa1.1 channel activator. Displays vasodilation and neuroprotective properties. Blood brain barrier permeable.

Solubility & Handling

Solubility overview Soluble in DMSO (100mM) or ethanol (15mM)
Storage instructions Room temperature
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use

Calculators

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Dilution

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Chemical Data

Purity >95%
Chemical name 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl]-1,3,4-oxadiazol-2( 3H)-one
Molecular Weight 370.71
Chemical structure BMS 191011  [202821-81-6] Chemical Structure
Molecular Formula C16H10ClF3N2O3
CAS Number 202821-81-6
PubChem identifier 10474339
SMILES OC1=CC=C(Cl)C=C1CN1N=C(OC1=O)C1=CC=C(C=C1)C(F)(F)F
InChi InChI=1S/C16H10ClF3N2O3/c17-12-5-6-13(23)10(7-12)8-22-15(24)25-14(21-22)9-1-3-11(4-2-9)16(18,19)20/h1-7,23H,8H2
InChiKey QKOWACXSXTXRKA-UHFFFAOYSA-N
MDL number MFCD09753285

References for BMS 191011

References are publications that support the biological activity of the product
  • BMS-191011, an opener of large-conductance Ca2+-activated potassium channels, dilates rat retinal arterioles in vivo.

    Mori A et al (2011) Biol Pharm Bull 34(1) : 150-2.
  • 3-[(5-Chloro-2-hydroxyphenyl)methyl]-5-[4-(trifluoromethyl)phenyl ]-1,3,4-oxadiazol-2(3H)-one, BMS-191011: opener of large-conductance Ca(2+)-activated potassium (maxi-K) channels, identification, solubility, and SAR.

    Romine JL et al (2007) J Med Chem 50(3) : 528-42.
  • Synthesis of water-soluble prodrugs of BMS-191011: a maxi-K channel opener targeted for post-stroke neuroprotection.

    Hewawasam P et al (2003) Bioorg Med Chem Lett 13(10) : 1695-8.

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