Product overview

Name Bisindolylmaleimide VIII
Description Potent, selective PKC inhibitor
Purity >98%
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Biological Data

Biological description Potent and selective protein kinase C inhibitor (IC50 = 158 nM). Displays selectivity for PKC-α over PKC-β1, PKC-βII, PKC-γ and PKC-ε (IC50 values are 53, 195, 163, 213, 175 nM respectively). Facilitates Fas-mediated apoptosis and enhances DR5 mediated apoptosis. Also CDK2 antagonist (IC50 = 600 nM).

Solubility & Handling

Solubility overview Soluble in DMSO or water
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name Ro 31-7549 acetate
Molecular Weight 458.6
Chemical structure Bisindolylmaleimide VIII [138516-31-1] Chemical Structure
Molecular Formula C24H22N4O2.C2H4O2
CAS Number 138516-31-1
PubChem identifier 9868770
SMILES CC(=O)O.CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCN

References for Bisindolylmaleimide VIII

References are publications that support the biological activity of the product
  • Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors.

    Brehmer D et al (2004) Mol Cell Proteomics 3(5) : 490-500.
  • Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways.

    Ohtsuka T et al (2002) J Biol Chem 277(32) : 29294-303.
  • Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.

    Zhou T et al (1999) Nat Med 5(1) : 42-8.
  • Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C.

    Wilkinson SE et al (1993) Biochem J 294 ( Pt 2) : 335-7.