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Bisindolylmaleimide VIII

(HB0141)
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Product overview

Name Bisindolylmaleimide VIII
Purity >98%
Description Potent, selective PKC inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4)
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Biological Data

Biological description Potent and selective protein kinase C inhibitor (IC50 = 158 nM). Displays selectivity for PKC-α over PKC-β1, PKC-βII, PKC-γ and PKC-ε (IC50 values are 53, 195, 163, 213, 175 nM respectively). Facilitates Fas-mediated apoptosis and enhances DR5 mediated apoptosis. Also CDK2 antagonist (IC50 = 600 nM).

Solubility & Handling

Solubility overview Soluble in DMSO or water
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name Ro 31-7549 acetate
Molecular Weight 458.6
Chemical structure Bisindolylmaleimide VIII [138516-31-1] Chemical Structure
Molecular Formula C24H22N4O2.C2H4O2
CAS Number 138516-31-1
PubChem identifier 9868770
SMILES CC(=O)O.CN1C=C(C2=CC=CC=C21)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCN

References for Bisindolylmaleimide VIII

References are publications that support the biological activity of the product

  • Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors.

    Brehmer D et al (2004) Mol Cell Proteomics 3(5) : 490-500.
    Read more (PubMedID: 14769951)

  • Bisindolylmaleimide VIII enhances DR5-mediated apoptosis through the MKK4/JNK/p38 kinase and the mitochondrial pathways.

    Ohtsuka T et al (2002) J Biol Chem 277(32) : 29294-303.
    Read more (PubMedID: 12034736)

  • Bisindolylmaleimide VIII facilitates Fas-mediated apoptosis and inhibits T cell-mediated autoimmune diseases.

    Zhou T et al (1999) Nat Med 5(1) : 42-8.
    Read more (PubMedID: 9883838)

  • Isoenzyme specificity of bisindolylmaleimides, selective inhibitors of protein kinase C.

    Wilkinson SE et al (1993) Biochem J 294 ( Pt 2) : 335-7.
    Read more (PubMedID: 8373348)

4 Item(s)

Grouped product items
Order: HB0141
Pack PriceQty
5mg
$355
10mg
$597
Potent, selective PKC inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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