Product overview

Name Bisindolylmaleimide V
Description Selective PKC / S6K inhibitor
Biological description Selective protein kinase C (PKC) inhibitor. Displays low affinity for muscarinic 1 receptor (Kd = 100 µM). Also mitogen-stimulated protein kinase p70s6k/p85s6k (S6K) inhibitor (IC50 = 8.0 µM). Displays cytoprotective effects
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Solubility & Handling

Solubility overview Soluble in DMSO or methanol
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Molecular Weight 341.3
Chemical structure Product image
Molecular Formula C21H15N3O2
CAS Number 113963-68-1
SMILES CN1C(=O)C(=C(C1=O)c2c[nH]c3ccccc23)c4c[nH]c5ccccc45

References for Bisindolylmaleimide V

References are publications that support the biological activity of the product
  • Bisindolylmaleimide I and V inhibit necrosis induced by oxidative stress in a variety of cells including neurons.

    Asakai R et al (2002) Neurosci Res 44(3) : 297-304.
  • Ro 31-6045, the inactive analogue of the protein kinase C inhibitor Ro 31-8220, blocks in vivo activation of p70(s6k)/p85(s6k): implications for the analysis of S6K signalling.

    Marmy-Conus N et al (2002) FEBS Lett 519(1-3) : 135-40.
  • Muscarinic interactions of bisindolylmaleimide analogues.

    Lazareno S et al (1998) Eur J Pharmacol 360(2-3) : 281-4.
  • The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.

    Toullec D et al (1991) J Biol Chem 266(24) : 15771-81.