Product overview

Name Bisindolylmaleimide IV
Purity >98%
Description Selective, non-competitive PKC / PKA inhibitor
Write Your Own Review
You're reviewing:Bisindolylmaleimide IV
Rate this item:

Biological Data

Biological description Selective and non-competitive protein kinase C (PKC) inhibitor (IC50 = 0.1 µM). Also inhibits protein kinase A (PKA) (IC50 = 2.0 µM). Blocks PLC/PKC signalling to block melatonin-induced potentiation of glycine currents in the retina.

Solubility & Handling

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.



More Info


More Info

Chemical Data

Purity >98%
Chemical name Arcyriarubin A
Molecular Weight 327.34
Chemical structure Bisindolylmaleimide IV  [119139-23-0] Chemical Structure
Molecular Formula C20H13N3O2
CAS Number 119139-23-0
PubChem identifier 2399

References for Bisindolylmaleimide IV

References are publications that support the biological activity of the product
  • Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form.

    Gould CM et al (2011) J Biol Chem 286(33) : 28922-30.
  • Protein kinase C masks nitric oxide synthase activity in vascular smooth muscle under basal conditions.

    Kline LW et al (2004) J Cardiovasc Pharmacol 43(2) : 281-7.
  • Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides.

    Davis PD et al (1992) J Med Chem 35(1) : 177-84.
  • The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.

    Toullec D et al (1991) J Biol Chem 266(24) : 15771-81.

4 Item(s)