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Bisindolylmaleimide IV

(HB0137)
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Product overview

Name Bisindolylmaleimide IV
Purity >98%
Description Selective, non-competitive PKC / PKA inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4)
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Biological Data

Biological description Selective and non-competitive protein kinase C (PKC) inhibitor (IC50 = 0.1 µM). Also inhibits protein kinase A (PKA) (IC50 = 2.0 µM). Blocks PLC/PKC signalling to block melatonin-induced potentiation of glycine currents in the retina.

Solubility & Handling

Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name Arcyriarubin A
Molecular Weight 327.34
Chemical structure Bisindolylmaleimide IV [119139-23-0] Chemical Structure
Molecular Formula C20H13N3O2
CAS Number 119139-23-0
PubChem identifier 2399
SMILES C1=CC=C2C(=C1)C(=CN2)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54

References for Bisindolylmaleimide IV

References are publications that support the biological activity of the product

  • Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form.

    Gould CM et al (2011) J Biol Chem 286(33) : 28922-30.
    Read more (PubMedID: 21715334)

  • Protein kinase C masks nitric oxide synthase activity in vascular smooth muscle under basal conditions.

    Kline LW et al (2004) J Cardiovasc Pharmacol 43(2) : 281-7.
    Read more (PubMedID: 14716218)

  • Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides.

    Davis PD et al (1992) J Med Chem 35(1) : 177-84.
    Read more (PubMedID: 1732526)

  • The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.

    Toullec D et al (1991) J Biol Chem 266(24) : 15771-81.
    Read more (PubMedID: 1874734)

4 Item(s)

Grouped product items
Order: HB0137
Pack PriceQty
5mg
$251
Selective, non-competitive PKC / PKA inhibitor
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