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Bisindolylmaleimide IV

(HB0137)
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Product overview

Name Bisindolylmaleimide IV
Purity >98%
Description Selective, non-competitive PKC / PKA inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (4)
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Biological Data

Biological description Selective and non-competitive protein kinase C (PKC) inhibitor (IC50 = 0.1 µM). Also inhibits protein kinase A (PKA) (IC50 = 2.0 µM). Blocks PLC/PKC signalling to block melatonin-induced potentiation of glycine currents in the retina.

Solubility & Handling

Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name Arcyriarubin A
Molecular Weight 327.34
Chemical structure Bisindolylmaleimide IV [119139-23-0] Chemical Structure
Molecular Formula C20H13N3O2
CAS Number 119139-23-0
PubChem identifier 2399
SMILES C1=CC=C2C(=C1)C(=CN2)C3=C(C(=O)NC3=O)C4=CNC5=CC=CC=C54

References for Bisindolylmaleimide IV

References are publications that support the biological activity of the product

  • Active site inhibitors protect protein kinase C from dephosphorylation and stabilize its mature form.

    Gould CM et al (2011) J Biol Chem 286(33) : 28922-30.
    Read more (PubMedID: 21715334)

  • Protein kinase C masks nitric oxide synthase activity in vascular smooth muscle under basal conditions.

    Kline LW et al (2004) J Cardiovasc Pharmacol 43(2) : 281-7.
    Read more (PubMedID: 14716218)

  • Inhibitors of protein kinase C. 1. 2,3-Bisarylmaleimides.

    Davis PD et al (1992) J Med Chem 35(1) : 177-84.
    Read more (PubMedID: 1732526)

  • The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.

    Toullec D et al (1991) J Biol Chem 266(24) : 15771-81.
    Read more (PubMedID: 1874734)

4 Item(s)

Grouped product items
Order: HB0137
Pack PriceQty
5mg
$259
Selective, non-competitive PKC / PKA inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

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