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Biological Data
| Biological description | Selective protein kinase C (PKC) inhibitor. Competitive NQO2 inhibitor (Ki = 16.5 µM) and Ste20-related kinase (SLK) inhibitor (IC50 = 170 nM). Shows inhibitory action at PKCα, MSK1, MAPKAP-K1β, S6K1 and AMPK. Also CDK2 inhibitor (IC50 = 2 µM). |
Solubility & Handling
| Solubility overview | Soluble in methanol or DMSO |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical structure | ![Bisindolylmaleimide III [137592-43-9] Chemical Structure](data:image/png;base64,iVBORw0KGgoAAAANSUhEUgAAAAEAAAABCAQAAAC1HAwCAAAAC0lEQVR4nGP6zwAAAgcBApocMXEAAAAASUVORK5CYII= "Bisindolylmaleimide III [137592-43-9]") |
| Molecular Formula | C23H20N4O2 |
| SMILES | C1=CC=C2C(=C1)C(=CN2)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCN |
References for Bisindolylmaleimide III
References are publications that support the biological activity of the product
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Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors.
Brehmer D et al (2004) Mol Cell Proteomics 3(5) : 490-500. -
Specificity and mechanism of action of some commonly used protein kinase inhibitors.
Davies SP et al (2000) Biochem J 351(Pt 1) : 95-105. -
The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.
Toullec D et al (1991) J Biol Chem 266(24) : 15771-81.
![Bisindolylmaleimide III [137592-43-9] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0136.png "Bisindolylmaleimide III [137592-43-9]")
Understanding purity and quality - a guide for life scientists