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Bisindolylmaleimide III

(HB0136)
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Product overview

Name Bisindolylmaleimide III
Purity >98%
Description Selective PKC inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description Selective protein kinase C (PKC) inhibitor. Competitive NQO2 inhibitor (Ki = 16.5 µM) and Ste20-related kinase (SLK) inhibitor (IC50 = 170 nM). Shows inhibitory action at PKCα, MSK1, MAPKAP-K1β, S6K1 and AMPK. Also CDK2 inhibitor (IC50 = 2 µM).

Solubility & Handling

Solubility overview Soluble in methanol or DMSO
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >98%
Chemical name BIM III
Molecular Weight 384.43
Chemical structure Bisindolylmaleimide III [137592-43-9] Chemical Structure
Molecular Formula C23H20N4O2
CAS Number 137592-43-9
PubChem identifier 2398
SMILES C1=CC=C2C(=C1)C(=CN2)C3=C(C(=O)NC3=O)C4=CN(C5=CC=CC=C54)CCCN

References for Bisindolylmaleimide III

References are publications that support the biological activity of the product

  • Proteome-wide identification of cellular targets affected by bisindolylmaleimide-type protein kinase C inhibitors.

    Brehmer D et al (2004) Mol Cell Proteomics 3(5) : 490-500.
    Read more (PubMedID: 14769951)

  • Specificity and mechanism of action of some commonly used protein kinase inhibitors.

    Davies SP et al (2000) Biochem J 351(Pt 1) : 95-105.
    Read more (PubMedID: 10998351)

  • The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C.

    Toullec D et al (1991) J Biol Chem 266(24) : 15771-81.
    Read more (PubMedID: 1874734)

3 Item(s)

Grouped product items
Order: HB0136
Pack PriceQty
5mg
$208
Selective PKC inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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