Potent protein kinase C (PKC) inhibitor (IC50 = 0.10 µM). Displays less activity at protein kinase A (PKA) and pyruvate kinase (PK) (IC50 values are 2.0 and 0.70 µM respectively).Also β1.3 subunit of Kv 1.5 channel inhibitor (IC50 = 12.4 µM) and non-competitive nicotonic cholinergic receptor antagonist (approx IC50 = 0.031 µM).
Solubility & Handling
Storage instructions
-20°C
Solubility overview
Soluble in DMSO (100mM)
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chromaffin cell catecholamine secretion: bisindolylmaleimide compounds exhibit novel and potent antagonist effects at the nicotinic cholinergic receptor in pheochromocytoma cells.
Mahata M et al (2002) Mol Pharmacol 61(6) : 1340-7.
![Bisindolylmaleimide II [137592-45-1] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb0135.png "Bisindolylmaleimide II [137592-45-1]")
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