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Benidipine hydrochloride

(HB1216)
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Product overview

Name Benidipine hydrochloride
Alternative names KW 3049
Purity >99%
Description Ca2+ channel inhibitor
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3)
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Biological Data

Biological description L-, N- and T-type Ca2+ channel inhibitor (IC50 = 2.7 nM for ICa inhibition). Inhibits the activation of aldosterone-induced mineralocorticoid receptor. Shows anti-atherosclerotic, antihypertensive and cardioprotective actions.

Solubility & Handling

Solubility overview Soluble in DMSO (75mM) or ethanol (10mM)
Storage instructions room temperature (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name (4R)-rel-1,4-Dihydro-2,6-dimethyl-4 -(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[(3R)-1-(phenylmethyl)-3-piperidinyl] ester hydrochloride
Molecular Weight 542.02
Chemical structure Benidipine hydrochloride [91599-74-5] Chemical Structure
Molecular Formula C28H31N3O6.HCl
CAS Number 91599-74-5
PubChem identifier 76968919
SMILES CC1=C(C(OC)=O)[C@@H]([C@]2=CC([N+]([O-])=O)=CC=C2)C(C(O[C@H]3CN(CC4=CC=CC=C4)CCC3)=O)=C(C)N1.CC5=C(C(OC)=O)[C@H]([C@]6=CC([N+]([O-])=O)=CC=C6)C(C(O[C@@H]7CN(CC8=CC=CC=C8)CCC7)=O)=C(C)N5.Cl.Cl
InChiKey SPMJXDRNJQIBTB-IMEZZWDRSA-N

References for Benidipine hydrochloride

References are publications that support the biological activity of the product

  • The L-, N-, and T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family.

    Kosaka H et al (2010) Eur J Pharmacol 635(1-3) : 49-55.
    Read more (PubMedID: 20307534)

  • Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel, long-acting calcium channel blocker.

    Yao K et al (2006) J Pharmacol Sci 100(4) : 243-61.
    Read more (PubMedID: 16565579)

  • Mechanisms of long-lasting effects of benidipine on Ca current in guinea-pig ventricular cells.

    Yamamoto M et al (1990) Br J Pharmacol 100(4) : 669-76.
    Read more (PubMedID: 2169935)

3 Item(s)

Grouped product items
Order: HB1216
Pack PriceQty
100mg
$535
Ca2+ channel inhibitor
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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