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Biological Data Biological description L-, N- and T-type Ca2+ channel inhibitor (IC50 = 2.7 nM for ICa inhibition). Inhibits the activation of aldosterone-induced mineralocorticoid receptor. Shows anti-atherosclerotic, antihypertensive and cardioprotective actions.
Solubility & Handling Storage instructions room temperature (desiccate)
Solubility overview Soluble in DMSO (75mM) or ethanol (10mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name (4R )-rel -1,4-Dihydro-2,6-dimethyl-4 -(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-[(3R )-1-(phenylmethyl)-3-piperidinyl] ester hydrochloride
Chemical structure
Molecular Formula C28 H31 N3 O6 .HCl
PubChem identifier 76968919
SMILES CC1=C(C(OC)=O)[C@@H]([C@]2=CC([N+]([O-])=O)=CC=C2)C(C(O[C@H]3CN(CC4=CC=CC=C4)CCC3)=O)=C(C)N1.CC5=C(C(OC)=O)[C@H]([C@]6=CC([N+]([O-])=O)=CC=C6)C(C(O[C@@H]7CN(CC8=CC=CC=C8)CCC7)=O)=C(C)N5.Cl.Cl
InChiKey SPMJXDRNJQIBTB-IMEZZWDRSA-N
References for Benidipine hydrochloride References are publications that support the biological activity of the product
The L-, N-, and T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family. Kosaka H et al (2010) Eur J Pharmacol 635(1-3) : 49-55. Pharmacological, pharmacokinetic, and clinical properties of benidipine hydrochloride, a novel, long-acting calcium channel blocker. Yao K et al (2006) J Pharmacol Sci 100(4) : 243-61. Mechanisms of long-lasting effects of benidipine on Ca current in guinea-pig ventricular cells. Yamamoto M et al (1990) Br J Pharmacol 100(4) : 669-76.
![Benidipine hydrochloride [91599-74-5] Chemical Structure](https://cdn.hellobio.com/media/catalog/product//h/b/hb1216.png "Benidipine hydrochloride [91599-74-5]")
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