L-, N- and T-type Ca2+ channel inhibitor (IC50 = 2.7 nM for ICa inhibition). Inhibits the activation of aldosterone-induced mineralocorticoid receptor. Shows anti-atherosclerotic, antihypertensive and cardioprotective actions.
Solubility & Handling
Solubility overview
Soluble in DMSO (75mM) or ethanol (10mM)
Storage instructions
room temperature (desiccate)
Storage of solutions
Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions
Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important
This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
References are publications that support the biological activity of the product
The L-, N-, and T-type triple calcium channel blocker benidipine acts as an antagonist of mineralocorticoid receptor, a member of nuclear receptor family.
Kosaka H et al (2010) Eur J Pharmacol 635(1-3) : 49-55.