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Biological Data
| Biological description | Cytochrome C-dependent caspase activator. Increases Apaf-1 oligomerization forming apoptosomes. Activates caspase-3 following caspase-9 activation. Induces PARP cleavage and DNA fragmentation. Shows apoptotic and anti-cancer actions. |
Solubility & Handling
| Storage instructions | Room temperature |
| Solubility overview | Soluble in ethanol (5mM) or DMSO (100mM) |
| Important | This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use. |
Chemical Data
| Chemical name | 1-[(3,4-Dichlorophenyl)methyl]-1H-indole-2,3-dione |
| Molecular Formula | C15H9Cl2NO2 |
| PubChem identifier | 1901244 |
| SMILES | ClC1=CC=C(CN2C(=O)C(=O)C3=CC=CC=C23)C=C1Cl |
| InChiKey | KGRJPLRFGLMQMV-UHFFFAOYSA-N |
References for Apoptosis Activator 2
References are publications that support the biological activity of the product
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Nano - drug Delivery of Apoptosis Activator 2 to AGS Cells by Liposomes Conjugated with Anti-TROP2 Antibody.
Farivar TN et al (2012) N Am J Med Sci 4(11) : 582-5. -
Elevated P75NTR expression causes death of engrailed-deficient midbrain dopaminergic neurons by Erk1/2 suppression.
Alavian KN et al (2009) Neural Dev 4 : 11 -
Direct activation of the apoptosis machinery as a mechanism to target cancer cells.
Nguyen JT et al (2003) Proc Natl Acad Sci U S A 100(13) : 7533-8.
Caspase activator. Apoptosis inducer.
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