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Images AMTB hydrochloride product vial image | Hello Bio
AMTB hydrochloride product vial image | Hello Bio Biological Data Biological description TRPM8 channel blocker (pIC50 = 6.23). Exhibits selectivity for TRPM8 channels over TRPV1 and TRPV4 channels. Displays antiproliferative properties.
Solubility & Handling Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100mM) and in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.
Chemical Data Chemical name N -(3-Aminopropyl)-2-[(3-methylpheny l)methoxy]-N -(2-thienylmethyl)benzamide hydrochloride
Chemical structure
Molecular Formula C23 H26 N2 O2 S.HCl
PubChem identifier 16095383
SMILES CC1=CC(=CC=C1)COC2=CC=CC=C2C(=O)N(CCCN)CC3=CC=CS3.Cl
InChi InChI=1S/C23H26N2O2S.ClH/c1-18-7-4-8-19(15-18)17-27-22-11-3-2-10-21(22)23(26)25(13-6-12-24)16-20-9-5-14-28-20;/h2-5,7-11,14-15H,6,12-13,16-17,24H2,1H3;1H
InChiKey UDXGBANGPYONOK-UHFFFAOYSA-N
References for AMTB hydrochloride References are publications that support the biological activity of the product
Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor. Morgan K et al (2014) Biosci Rep 34(4) : TRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells. Valero ML et al (2012) PLoS One 7(12) : e51825. AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome. Lashinger ES et al (2008) Am J Physiol Renal Physiol 295(3) : F803-10.
![AMTB hydrochloride [926023-82-7] Chemical Structure](https://hellobio.com/media/catalog/product//h/b/hb1167.png "AMTB hydrochloride [926023-82-7]")
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