Product overview

Name AMTB hydrochloride
Description TRPM8 channel blocker
Biological description TRPM8 channel blocker (pIC50 = 6.23). Exhibits selectivity for TRPM8 channels over TRPV1 and TRPV4 channels. Displays antiproliferative properties.
Purity >99%
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Solubility & Handling

Storage instructions Room temperature (desiccate)
Solubility overview Soluble in water (100mM) and in DMSO (100mM)
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

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Dilution

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Chemical Data

Chemical name N-(3-Aminopropyl)-2-[(3-methylpheny l)methoxy]-N-(2-thienylmethyl)benzamide hydrochloride
Molecular Weight 430.99
Chemical structure Product image
Molecular Formula C23H26N2O2S.HCl
CAS Number 926023-82-7
PubChem identifier 16095383
SMILES CC1=CC(=CC=C1)COC2=CC=CC=C2C(=O)N(CCCN)CC3=CC=CS3.Cl
InChi InChI=1S/C23H26N2O2S.ClH/c1-18-7-4-8-19(15-18)17-27-22-11-3-2-10-21(22)23(26)25(13-6-12-24)16-20-9-5-14-28-20;/h2-5,7-11,14-15H,6,12-13,16-17,24H2,1H3;1H
InChiKey UDXGBANGPYONOK-UHFFFAOYSA-N

References for AMTB hydrochloride

References are publications that support the biological activity of the product
  • TRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells.

    Valero ML et al (2012) PLoS One 7(12) : e51825.
  • AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome.

    Lashinger ES et al (2008) Am J Physiol Renal Physiol 295(3) : F803-10.
  • Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor.

    Morgan K et al (2014) Biosci Rep 34(4) :