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AMTB hydrochloride

(HB1167)
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Product overview

Name AMTB hydrochloride
Purity >99%
Description TRPM8 channel blocker
Biological Data Solubility & Handling Chemical Data Related Areas Calculators Technical guides (1) Reviews References (3) Frequently bought together
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AMTB hydrochloride product vial image | Hello Bio
AMTB hydrochloride product vial image | Hello Bio

AMTB hydrochloride product vial image | Hello Bio

AMTB hydrochloride product vial image | Hello Bio

Biological Data

Biological description TRPM8 channel blocker (pIC50 = 6.23). Exhibits selectivity for TRPM8 channels over TRPV1 and TRPV4 channels. Displays antiproliferative properties.

Solubility & Handling

Solubility overview Soluble in water (100mM) and in DMSO (100mM)
Storage instructions Room temperature (desiccate)
Storage of solutions Prepare and use solutions on the same day if possible. Store solutions at -20°C for up to one month if storage is required. Equilibrate to RT and ensure the solution is precipitate free before use.
Shipping Conditions Stable for ambient temperature shipping. Follow storage instructions on receipt.
Important This product is for RESEARCH USE ONLY and is not intended for therapeutic or diagnostic use. Not for human or veterinary use.

Calculators

Molarity

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Dilution

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Chemical Data

Purity >99%
Chemical name N-(3-Aminopropyl)-2-[(3-methylpheny l)methoxy]-N-(2-thienylmethyl)benzamide hydrochloride
Molecular Weight 430.99
Chemical structure AMTB hydrochloride [926023-82-7] Chemical Structure
Molecular Formula C23H26N2O2S.HCl
CAS Number 926023-82-7
PubChem identifier 16095383
SMILES CC1=CC(=CC=C1)COC2=CC=CC=C2C(=O)N(CCCN)CC3=CC=CS3.Cl
InChi InChI=1S/C23H26N2O2S.ClH/c1-18-7-4-8-19(15-18)17-27-22-11-3-2-10-21(22)23(26)25(13-6-12-24)16-20-9-5-14-28-20;/h2-5,7-11,14-15H,6,12-13,16-17,24H2,1H3;1H
InChiKey UDXGBANGPYONOK-UHFFFAOYSA-N

References for AMTB hydrochloride

References are publications that support the biological activity of the product

  • Human TRPM8 and TRPA1 pain channels, including a gene variant with increased sensitivity to agonists (TRPA1 R797T), exhibit differential regulation by SRC-tyrosine kinase inhibitor.

    Morgan K et al (2014) Biosci Rep 34(4) :
    Read more (PubMedID: 24975826)

  • TRPM8 ion channels differentially modulate proliferation and cell cycle distribution of normal and cancer prostate cells.

    Valero ML et al (2012) PLoS One 7(12) : e51825.
    Read more (PubMedID: 23251635)

  • AMTB, a TRPM8 channel blocker: evidence in rats for activity in overactive bladder and painful bladder syndrome.

    Lashinger ES et al (2008) Am J Physiol Renal Physiol 295(3) : F803-10.
    Read more (PubMedID: 18562636)

3 Item(s)

Grouped product items
Order: HB1167
Pack PriceQty
5mg
$100
25mg
$397
TRPM8 channel blocker
Shipping Info

Standard: $35

Hazardous: $35

Shipped on ice: $35

Shipping will be calculated at checkout

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